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FLASH GENE

Symbol

MFSD10

contributors: mct/npt - updated : 14-11-2019

HGNC name	major facilitator superfamily domain containing 10
HGNC id	16894

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p16.3      Physical location : 2.932.289 - 2.936.586
Synonym name	tetracycline transporter-like protein
Synonym symbol(s)	TTL2, TETTRAN, TPO1, TETRAN, RP11-520M5.2, IT10C3

DNA

TYPE	functioning gene
STRUCTURE	4.30 kb     12 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map	pter - ZNF141 - D4S134 - PDE6B - IDUA - D4S96 - D4S115 - D4S168 - FGFR3 - D4S114 - D4S168 - COX6BP4 - D4S183 - D4S182 - ADD1 - MFSD10 - GRK4 - D4S127 - HD - D4S180 - D4S125 - LRPAP1 - ADRA2C - D4S10 - cen
Authors	Riess (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001363679 12 - 1648 NP_001350608 - 366 - 2008 18638446 NM_001146069 12 - 1717 NP_001139541 - 455 - 2008 18638446 NM_001120 12 - 1969 NP_001111 - 455 - 2008 18638446

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Lymphoid/Immune tonsils       highly Nervous nerve       highly Reproductive female system uterus cervix   highly   female system ovary     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

twelve membrane-spanning domains

HOMOLOGY

interspecies

ortholog to Drosophila Tpo1p

intraspecies	homolog to Drosophila Drtet
	homolog to E. coli tetracycline transporter (TetA)

Homologene

FAMILY	major facilitator superfamily
	tcr/tet family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nuclear envelope,int
text	predominantly localized on cytoplasmic membranes
	MFSD10, TMX4, and ARL6IP6 likely residing in the inner nuclear membrane

basic FUNCTION	having a tetracycline transporter activity
	functioning as a metal-tetracycline/h(+) antiporter
	efflux pump for non-steroidal anti-inflammatory drugs and the first major facilitator superfamily (MFS) protein identified that is involved in drug resistance in human cells
	new type of membrane transporter involved in the transport of non-steroidal anti-inflammatory drugs
	may be involved in the transport of organic anions across the luminal membranes of proximal tubules
	eosinophil-specific cell surface molecule

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS