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FLASH GENE
Symbol ZNF141 contributors: mct - updated : 03-09-2014
HGNC name zinc finger protein 141
HGNC id 12926
Location 4p16.3      Physical location : 331.595 - 367.691
Synonym name zinc finger protein 141 (clone pHZ-44)
Synonym symbol(s) pHZ-44, D4S90, PAPA6
DNA
TYPE functioning gene
STRUCTURE 36.32 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D4S142 - D4S90 /ZNF141 - PDE6B - MYL5 - IDUA /D4S111 - FGFR3 - cen
Authors Tommerup (93)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1643 55 474 - Tommerup (1993)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal Krüppel associated box (KRAB) domain
  • several zinc finger motifs C2H2 type,Krüppel-like
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • KRAB subfamily
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation as a repressor
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for Wolf-Hirschhorn (4p-) syndrome (Tommerup 1993)
    Marker
    Therapy target
    ANIMAL & CELL MODELS