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FLASH GENE
Symbol ADRA2C contributors: mct - updated : 12-03-2008
HGNC name adrenergic, alpha-2C-, receptor
HGNC id 283
Location 4p16.3-p15      Physical location : 3.768.295 - 3.770.251
Synonym name
  • alpha2-AR-C4
  • Synonym symbol(s) ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2C-AR
    DNA
    TYPE like-sequence
    STRUCTURE 1.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D4S95 - HD - D4S125 - D4S126 - D4S81 - ADRA2C - D4S10 - cen
    Authors Riess (94)
    Physical map
    LOC339985 4p16.3 hypothetical gene supported by BC010180 RNF4 4p16.3 ring finger protein 4 C4orf8 4p16.3 chromosome 4 open reading frame 8 TNIP2 4p16.3 TNFAIP3 interacting protein 2 LOC389196 4 LOC389196 SH3BP2 4p16.3 SH3-domain binding protein 2 ADD1 4p16.3 adducin 1 (alpha) TETRAN 4p16.3 tetracycline transporter-like protein C4orf9 4p16.3 chromosome 4 open reading frame 9 GPRK2L 4p16.3 G protein-coupled receptor kinase 2-like (Drosophila) HD 4p16.3 huntingtin (Huntington disease) LOC345222 4p16.3 hypothetical gene supported by BC043530 RGS12 4p16.3 regulator of G-protein signalling 12 HGFAC 4p16.3 HGF activator FLJ33718 4p16.3 hypothetical protein FLJ33718 LOC391612 4 similar to hypothetical protein MGC45871 LRPAP1 4p16.3 low density lipoprotein receptor-related protein associated protein 1 FLJ35424 4p16.3 hypothetical protein FLJ35424 ADRA2C 4p16.3-p15 adrenergic, alpha-2C-, receptor LOC391613 4 similar to mannosyltransferase LOC196483 LOC391614 4 similar to Alkaline sphingomyelinase LOC391615 4 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC391616 4 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 OR7E43P 4p16.1 olfactory receptor, family 7, subfamily E, member 43 pseudogene OTOP1 4p16.2 otopetrin 1 MGC13159 4p16.2 hypothetical protein MGC13159 LYAR 4p16.2 hypothetical protein FLJ20425 ZNF509 4p16.2 zinc finger protein 509 D4S234E 4p16.3 DNA segment on chromosome 4 (unique) 234 expressed sequence STX18 4p16.2 syntaxin 18 MSX1 4p16.3-p16.1 msh homeo box homolog 1 (Drosophila) LDHAL1 4p16.3-p15.3 lactate dehydrogenase A-like 1 LOC132870 4p16.2 hypothetical gene LOC132870 C17 4p16-p15 hypothetical gene LOC132870 HSA250839 4p16.2 gene for serine/threonine protein kinase
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systembreastmammary gland  
     female systemplacenta   
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons
  • involved in cold-induced constriction of cutaneous arteries
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by 17beta-estradiol by interacting with cell surface receptors (cause a cAMP/Rap2-dependent increase in ADRA2C transcription)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may contribute to pathological changes in vascular function
    Susceptibility to congestive heart failure
    Variant & Polymorphism SNP increasing the risk of congestive heart failure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS