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FLASH GENE
Symbol ADRA2C contributors: mct - updated : 12-03-2008
HGNC name adrenergic, alpha-2C-, receptor
HGNC id 283
Location 4p16.3-p15      Physical location : 3.768.295 - 3.770.251
Synonym name
  • alpha2-AR-C4
    • Synonym symbol(s) ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2C-AR
    DNA
    TYPE like-sequence
    STRUCTURE 1.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - D4S95 - HD - D4S125 - D4S126 - D4S81 - ADRA2C - D4S10 - cen
    Authors Riess (94)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systembreastmammary gland  
     female systemplacenta   
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM) receptor
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons
  • involved in cold-induced constriction of cutaneous arteries
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by 17beta-estradiol by interacting with cell surface receptors (cause a cAMP/Rap2-dependent increase in ADRA2C transcription)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may contribute to pathological changes in vascular function
    Susceptibility to congestive heart failure
    Variant & Polymorphism SNP increasing the risk of congestive heart failure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS