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FLASH GENE

Symbol

CLP1

contributors: mct - updated : 29-08-2016

HGNC name	CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
HGNC id	16999

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.12 kb     3 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006831 3 - 1864 NP_006822 47 425 - 2014 24766810 NM_001142597 3 - 1672 NP_001136069 - 361 - 2014 24766810

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Cardiovascular heart       highly Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans ATP-GTP binding protein (putative)

Homologene

FAMILY

Clp1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in the cleavage of the pre-mRNA
	phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage
	physiological role of CLP1 as the RNA kinase that phosphorylates the 5prime end of the 3prime exon during human tRNA splicing, allowing the subsequent ligation of both exon halves by an unknown tRNA ligase
	is a RNA kinase involved in tRNA splicing
	multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of pre-mRNA cleavage complex II

INTERACTION

DNA

RNA

small molecule

protein	CPSF1
	interacts with cleavage factor I

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PCH10

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS