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FLASH GENE
Symbol CLP1 contributors: mct - updated : 29-08-2016
HGNC name CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
HGNC id 16999
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans ATP-GTP binding protein (putative)
Homologene
FAMILY
  • Clp1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the cleavage of the pre-mRNA
  • phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage
  • physiological role of CLP1 as the RNA kinase that phosphorylates the 5prime end of the 3prime exon during human tRNA splicing, allowing the subsequent ligation of both exon halves by an unknown tRNA ligase
  • is a RNA kinase involved in tRNA splicing
  • multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of pre-mRNA cleavage complex II
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CPSF1
  • interacts with cleavage factor I
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS