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FLASH GENE
Symbol CLP1 contributors: mct - updated : 29-08-2016
HGNC name CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
HGNC id 16999
Corresponding disease
PCH10 pontocerebellar hypoplasia, type 10
Location 11q12.1      Physical location : 57.425.215 - 57.429.336
Synonym name
  • pre-mRNA cleavage complex II protein CLP1
  • homolog to a putative C elegans ATP-GTP binding protein
  • ATP/GTP binding protein
  • homolog of yeast CFIA subunit Clp1p
  • Synonym symbol(s) HCLP1, HEAB, HIS1
    EC.number 2.7.1.78
    DNA
    TYPE functioning gene
    STRUCTURE 4.12 kb     3 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1864 47 425 - 2014 24766810
    3 - 1672 - 361 - 2014 24766810
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   highly
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans ATP-GTP binding protein (putative)
    Homologene
    FAMILY
  • Clp1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the cleavage of the pre-mRNA
  • phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage
  • physiological role of CLP1 as the RNA kinase that phosphorylates the 5prime end of the 3prime exon during human tRNA splicing, allowing the subsequent ligation of both exon halves by an unknown tRNA ligase
  • is a RNA kinase involved in tRNA splicing
  • multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of pre-mRNA cleavage complex II
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CPSF1
  • interacts with cleavage factor I
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS