| protein
| TANK binding |
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associating with Borna disease virus protein (repressing its IFN-inducing kinase activity) |
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interacts with AZI2, SIKE, TICAM1/TRIF, IRF3 and DDX58 |
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binding partner for Optineurin (OPTN) |
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interacting with DDX3X |
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interacting with AKT1 (regulatory mechanism for AKT1 activation mediated by TBK1 and role of AKT1 in TLR-mediated immune responses)  |
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IKBKE/TBK1 mediate the activation of PELI1 E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 and TLR4 agonists |
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AKT1 is a direct TBK1 substrate that connects TBK1 to prosurvival signaling |
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physiological function of IKBKE/TBK1 in AKT1 regulation and a possible mechanism of IKBKE/TBK1 in oncogenesis by activating AKT1 |
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SERPINB2 and TGM2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation |
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NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 |
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TRAF6, was critical for IL17A-induced TRAF3IP2 phosphorylation, and for IL17A-induced TBK1 activation, its association with TRAF3IP2, and consequent TRAF3IP2 phosphorylation |
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negatively regulated IgA class switching by attenuating noncanonical signaling via the transcription factor NFKB1, an action that involved TBK1-mediated phosphorylation |
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TBK1 kinase addiction in lung cancer cells is mediated via autophagy of TAX1BP1/CALCOCO2 and non-canonical NFKB1 signalling |
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TRIM11 and TBK1, a key kinase that phosphorylates IRF3 in the DDX58 pathway, interacted with each other through CC and CC2 domain, respectively |
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in the presence of cytosolic DNA, rapidly traffics with TBK1 via VPS34-related autophagosomes to associate with endosomal compartments containing NFKB and IRF3 |
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TBK1 is a downstream kinase controlling dsDNA-mediated IRF3 and NFKB1 signaling dependent on TMEM173 |
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DOK3 was shown to bind TRAF3, and the binding of TRAF3 and TBK1 to DOK3 required the tyrosine-rich C-terminal domain of DOK3 |
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SIGLEC1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27 |
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DYRK2 phosphorylated Ser527 of TBK1, which is essential for the recruitment of NLRP4 and for the E3 ubiquitin ligase DTX4 to degrade TBK1 |
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TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NUMA1, and both CEP170 and NUMA1 are TBK1 substrates |
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constitutive interaction of TBK1 with OPTN and the ability of OPTN to bind to ubiquitin chains are essential for TBK1 recruitment and kinase activation on mitochondria |
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OPTN is a positive regulator TBK1 via a bipartite interaction between these molecules |
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SNRNP200 promotes viral RNA sensing and IRF3 activation through the ability of its N-terminal Sec63 domain (Sec63-1) to bind RNA and to interact with TBK1 |
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USP38 regulates TBK1 ubiquitination through the NLRP4 signalosome |
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PEBP1 is essential for TBK1 activation and type I interferon production triggered by viral infection |
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TBK1 negatively regulates the induction of a subset of genes by type I interferon receptor (IFNAR1) |
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TRIM23 mediates virus-induced autophagy via activation of TBK1 |
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unique innate immune activation cascade in which TBK1-IKBKB formed a positive feedback loop to assure robust cytokine production during CGAS-TMEM173 activation |
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through interacting with TBK1, HERPUD1 amplifies the MAVS signaling and facilitates the phosphorylation and nuclear translocation of IRF3 and NFKB1 to enhance the expression of IFNs, which leads to a broad inhibition of the replication of RNA viruses |
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mechanistically, USP1 and WDR48 bound to TBK1, removed its K48-linked polyubiquitination, and then reversed the degradation process of TBK1 |
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MVB12B is a target for TBK1 phosphorylation, which is essential for the sorting of DNA into extracellular vesicles (EVs) and stimulation of bystander cells |
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TBK1 acts redundantly with IKBKE to drive NFKB1 upon STING activation |
