| 1 | IKBKE, STING1, TBK1
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| TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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| Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D.
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| Cell Rep. Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. 2020
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| 2 | MVB12B, TBK1
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| Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. 2019. PMID:;
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| Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR.
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| Nat Microbiol. Apr;4(4):701-713. doi: 10.1038/s41564-019-0367-z. Epub 2019 Feb 25 2019
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| 3 | NLRP2, TBK1
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| NLRP2 negatively regulates antiviral immunity by interacting with TBK1.
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| Yang Y, Lang X, Sun S, Gao C, Hu J, Ding S, Li J, Li Y, Wang F, Gong T.
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| Eur J Immunol. Nov;48(11):1817-1825. doi: 10.1002/eji.201847589. Epub 2018 Sep 6 2018
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| 4 | HERPUD1, MAVS, TBK1
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| HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
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| Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K, Liu Y, Wu J.
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| J Immunol 199(9):3280-3292. doi: 10.4049/jimmunol.1700376. Epub 2017 Sep 27.
2017
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| 5 | TBK1, TRIM23
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| TRIM23 mediates virus-induced autophagy via activation of TBK1.
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| Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU.
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| Nat Microbiol at Microbiol. 2017 Sep 4. doi: 10.1038/s41564-017-0017-2. [Epub ahead of print] 2017
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| 6 | TBK1
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| TBK1 mutations in Italian patients with amyotrophic lateral sclerosis: genetic and functional characterisation.
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| Pozzi L, Valenza F, Mosca L, Dal Mas A, Domi T, Romano A, Tarlarini C, Falzone YM, Tremolizzo L, Sorarù G, Cerri F, Ferraro PM, Basaia S, Agosta F, Fazio R, Comola M, Comi G, Ferrari M, Quattrini A, Lunetta C, Penco S, Bonanomi D, Carrera P, Riva N.
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| J Neurol Neurosurg Psychiatry 88(10):869-875. doi: 10.1136/jnnp-2017-316174. Epub 2017 Aug 19.
2017
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| 7 | TBK1
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| The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.
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| Xiao Y, Zou Q, Xie X, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC.
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| J Exp Med 214(5):1493-1507. doi: 10.1084/jem.20161524. Epub 2017 Mar 29.
2017
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| 8 | CDON, TBK1
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| A novel function of TBK1 as a target of Cdon in oligodendrocyte differentiation and myelination.
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| Wang LC, Kennedy TE, Almazan G.
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| J Neurochem 140(3):451-462. doi: 10.1111/jnc.13882. Epub 2016 Nov 25.
2017
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| 9 | CGAS, IKBKB, STING1, TBK1
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| NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
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| Fang R, Wang C, Jiang Q, Lv M, Gao P, Yu X, Mu P, Zhang R, Bi S, Feng JM, Jiang Z.
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| J Immunol 199(9):3222-3233. doi: 10.4049/jimmunol.1700699. Epub 2017 Sep 22. 2017
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| 10 | TBK1, USP1, WDR48
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| USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
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| Yu Z, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L, Zhao W.
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| J Exp Med 214(12):3553-3563. doi: 10.1084/jem.20170180. Epub 2017 Nov 14.
2017
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| 11 | PEBP1, TBK1
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| RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity.
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| Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, Ye S, Huang H, Wang X.
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| EMBO J 35(23):2553-2565. Epub 2016 Oct 17.
2016
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| 12 | TBK1
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| Human TBK1: A Gatekeeper of Neuroinflammation.
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| Ahmad L, Zhang SY, Casanova JL, Sancho-Shimizu V.
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| Trends Mol Med 22(6):511-27. doi: 10.1016/j.molmed.2016.04.006. Review.
2016
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| 13 | OPTN, TBK1
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| The TBK1-binding domain of optineurin promotes type I interferon responses.
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| Meena NP, Zhu G, Mittelstadt PR, Giardino Torchia ML, Pourcelot M, Arnoult D, Ashwell JD, Munitic I.
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| FEBS Lett 590(10):1498-508. doi: 10.1002/1873-3468.12176. Epub 2016 May 4.
2016
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| 14 | OPTN, TBK1
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| Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
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| Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I.
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| Proc Natl Acad Sci U S A 113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30.
2016
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| 15 | IRF3, SNRNP200, TBK1
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| Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
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| Tremblay N, Baril M, Chatel-Chaix L, Es-Saad S, Park AY, Koenekoop RK, Lamarre D.
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| PLoS Pathog 12(7):e1005772. doi: 10.1371/journal.ppat.1005772. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2017 Jan 24;13(1):e1006174.
2016
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| 16 | DTX4, NLRP4, TBK1, USP38
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| USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.
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| Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W,Qin Y, Wang RF, Cui J.
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| Mol Cell. Oct 20;64(2):267-281. doi: 10.1016/j.molcel.2016.08.029. Epub 2016 Sep 29 2016
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| 17 | FTDALS4, TBK1
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| Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
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| Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH.
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| Nat Neurosci 18(5):631-6. doi: 10.1038/nn.4000. Epub 2015 Mar 24.
2015
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| 18 | FTDALS4, TBK1
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| Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease.
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| Pottier C, Bieniek KF, Finch N, van de Vorst M, Baker M, Perkersen R, Brown P, Ravenscroft T, van Blitterswijk M, Nicholson AM, DeTure M, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Boylan KB, Boeve BF, Graff-Radford NR, Veltman JA, Gilissen C, Murray ME, Dickson DW, Rademakers R.
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| Acta Neuropathol 130(1):77-92. doi: 10.1007/s00401-015-1436-x. Epub 2015 May 6.
2015
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| 19 | CEP170, NUMA1, TBK1
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| Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
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| Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S.
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| Nat Commun 6:10072. doi: 10.1038/ncomms10072.
2015
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| 20 | SIGLEC1, TBK1, TRIM27
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| Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.
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| Zheng Q, Hou J, Zhou Y, Yang Y, Xie B, Cao X.
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| Cell Res 25(10):1121-36. doi: 10.1038/cr.2015.108. Epub 2015 Sep 11.
2015
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| 21 | DTX4, DYRK2, NLRP4, TBK1
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| DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation.
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| An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu S.
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| PLoS Pathog Sep 25;11(9):e1005179. doi: 10.1371/journal.ppat.1005179. eCollection 2015 Sep. 2015
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| 22 | DOK3, TBK1, TRAF3
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| DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation.
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| Kim SS, Lee KG, Chin CS, Ng SK, Pereira NA, Xu S, Lam KP.
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| J Immunol 193(2):840-8. doi: 10.4049/jimmunol.1301601. Epub 2014 Jun 13.
2014
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| 23 | TBK1
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| TBK1 gene duplication and normal-tension glaucoma.
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| Ritch R, Darbro B, Menon G, Khanna CL, Solivan-Timpe F, Roos BR, Sarfarzi M, Kawase K, Yamamoto T, Robin AL, Lotery AJ, Fingert JH.
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| JAMA Ophthalmol 132(5):544-8. doi: 10.1001/jamaophthalmol.2014.104.
2014
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| 24 | IRF3, STING1, TBK1
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| Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
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| Abe T, Barber GN.
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| J Virol 88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. 2014
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| 25 | IRF3, STING1, TBK1, ULK1
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| Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
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| Konno H, Konno K, Barber GN.
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| Cell 155(3):688-98. doi: 10.1016/j.cell.2013.09.049. Epub 2013 Oct 10. 2013
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| 26 | DDX58, IFNB1, TBK1, TRIM11
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| TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1.
|
| Lee Y, Song B, Park C, Kwon KS.
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| PLoS One 8(5):e63255. doi: 10.1371/journal.pone.0063255. Print 2013. 2013
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| 27 | NFKB1, TBK1
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| The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.
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| Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC.
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| Nat Immunol 13(11):1101-9. doi: 10.1038/ni.2423. Epub 2012 Sep 30.
2012
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| 28 | SERPINB2, TBK1, TGM2
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| TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
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| Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M.
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| Proc Natl Acad Sci U S A 109(4):E177-86. doi: 10.1073/pnas.1119296109. Epub 2011 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4332–5 2012
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| 29 | IL17A, TBK1, TRAF3IP2, TRAF6
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| TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.
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| Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y.
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| Mol Cell Biol 32(19):3925-37. doi: 10.1128/MCB.00268-12. Epub 2012 Jul 30.
2012
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| 30 | CALCOCO2, TAX1BP1, TBK1
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| TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.
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| Newman AC, Scholefield CL, Kemp AJ, Newman M, McIver EG, Kamal A, Wilkinson S.
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| PLoS One 7(11):e50672. doi: 10.1371/journal.pone.0050672. Epub 2012 Nov 29.
2012
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| 31 | DTX4, NLRP4, TBK1
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| NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
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| Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF.
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| Nat Immunol. Mar 4;13(4):387-95. doi: 10.1038/ni.2239 2012
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| 32 | AKT1, TBK1, TICAM2
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| Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
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| Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY.
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| J Immunol 186(1):499-507. Epub 2010 Nov 24.
2011
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| 33 | PELI1, TBK1
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| The role of TBK1 and IKKε in the expression and activation of Pellino 1.
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| Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC.
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| Biochem J 434(3):537-48. 2011
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| 34 | AKT1, TBK1
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| TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
|
| Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA.
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| Mol Cell 41(4):458-70.
2011
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| 35 | AKT1, IKBKE, TBK1
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| IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
|
| Guo JP, Coppola D, Cheng JQ.
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| J Biol Chem 286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9.
2011
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| 36 | AKT1, IKBKE, TBK1
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| IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
|
| Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.
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| Proc Natl Acad Sci U S A 108(16):6474-9. Epub 2011 Apr 4.
2011
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| 37 | IKBKE, PELI1, TBK1
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| The role of TBK1 and IKKε in the expression and activation of Pellino 1.
|
| Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC.
|
| Biochem J 434(3):537-48.
2011
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| 38 | OPTN, TBK1
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| TBK1 mediates crosstalk between the innate immune response and autophagy.
|
| Weidberg H, Elazar Z.
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| Sci Signal 4(187):pe39. doi: 10.1126/scisignal.2002355. Review.
2011
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| 39 | TBK1
|
| Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality.
|
| Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, Goutagny N, Kuang W, Askew GR, Roberts V, Benoit S, Zhou T, Ling V, Pfeifer R, Stedman N, Fitzgerald KA, Lin LL, Hall JP.
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| J Leukoc Biol 88(6):1171-80. Epub 2010 Jul 22.
2010
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| 40 | TBK1
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| The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1.
|
| Kim HR, Lee SH, Jung G.
|
| FEBS Lett 584(3):525-30. Epub 2009 Dec 3.
2010
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| 41 | IRF3, TBK1
|
| TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
|
| Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G.
|
| J Immunol 182(4):2248-57.
2009
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| 42 | TBK1
|
| TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
|
| Muñoz MC, Giani JF, Mayer MA, Toblli JE, Turyn D, Dominici FP.
|
| J Endocrinol 201(2):185-97. Epub 2009 Feb 27.
2009
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| 43 | TBK1, GLC1E, SIKE
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| Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.
|
| Morton S, Hesson L, Peggie M, Cohen P.
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| FEBS Lett 582(6):997-1002. Epub 2008 Feb 26. 2008
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| 44 | DDX3X, TBK1
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| The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
|
| Soulat D, Bürckstümmer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G.
|
| EMBO J 27(15):2135-46. Epub 2008 Jun 26.
2008
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| 45 | TBK1
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| Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1.
|
| Deng W, Shi M, Han M, Zhong J, Li Z, Li W, Hu Y, Yan L, Wang J, He Y, Tang H, Deubel V, Luo X, Ning Q, Sun B.
|
| J Biol Chem 283(51):35590-7. Epub 2008 Oct 31.
2008
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| 46 | IKBKE, TBK1
|
| Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
|
| Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A.
|
| J Biol Chem 282(43):31131-46. Epub 2007 Sep 6. 2007
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| 47 | TBK1, IRF3
|
| Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.
|
| Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, Heins G, Ehrhardt C, Wolff T.
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| Proc Natl Acad Sci U S A 102(38):13640-5. Epub 2005 Sep 9. 2005
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| 48 | IKBKE, SIKE, TBK1
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| SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
|
| Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.
|
| EMBO J 24(23):4018-28. Epub 2005 Nov 10. 2005
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| 49 | IKBKE, IKBKG, TANK, TBK1
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| Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
|
| Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U.
|
| J Biol Chem 277(40):37029-36. 2002
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| 50 | IKBKE, TBK1
|
| IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
|
| Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A, Boddupalli H, Combs RG, Kretzmer K, Tripp CS.
|
| J Biol Chem 277(16):13840-7. 2002
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| 51 | TBK1
|
| NAK is an IkappaB kinase-activating kinase.
|
| Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M.
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| Nature 404(6779):778-82. 2000
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| 52 | TBK1
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| NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
|
| Pomerantz JL, Baltimore D.
|
| EMBO J 18(23):6694-704. 1999
|