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GENATLAS PHENOTYPE

last update : 26-10-2017

Symbol	FTDALS4
Location	12q14.2
Name	frontotemporal dementia and/or amyotrophic lateral sclerosis 4
Corresponding gene	TBK1
Main clinical features	neurodegenerative disorder characterized by adult or late adult onset of cognitive impairment, behavioral abnormalities, and speech apraxia and/or upper and lower motor neuron signs; mean age at onset was 60 years cognitive impairment, often progressing to fulminant FTD; bulbar symptoms were reported in 87% of patients during the disease course
Genetic determination	autosomal dominant
Function/system disorder	neurology
	neuromuscular
Type	disease

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