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FLASH GENE
Symbol ABR contributors: mct - updated : 21-05-2011
HGNC name active BCR-related gene
HGNC id 81
DNA
TYPE functioning gene
STRUCTURE 183.86 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - PFN1 - PAFAH1B1 - CRK - ABR - cen
Authors Morris (95)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 5603 - 822 - 1995 7479768
23 - 5300 - 859 - 1995 7479768
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to BCR
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text BCR and its close relative active BCR-related (ABR) localize at excitatory synapses
basic FUNCTION
  • ABR and BCR are the only GTPase-activating proteins to date that specifically negatively regulate Rac function in primary macrophages
  • GTPase-activating protein for the small GTPase Rac
  • BCR and ABR cooperate in negatively regulating acute inflammatory responses
  • BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interact with DLG4, an abundant postsynaptic scaffolding protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS