| Symbol
| IGF1R
| contributors: mct/npt/pgu - updated : 02-07-2019
|
| HGNC name
| insulin-like growth factor 1 receptor
|
| HGNC id
| 5465
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in breast and prostate cancer where it functions as an anti-apoptotic agent by enhancing cell survival | | constitutional
| germinal mutation
|
|
|
|
associated with an insensitivity to IGF1 due to IGF1R haploinsufficiency  | | constitutional
| germinal mutation
|
|
|
| |
in intrauterine and postnatal growth retardation | |
| Susceptibility
|
to breast cancer with poor survival to spontaneous preterm birth |
| Variant & Polymorphism
SNP
, other
| polymorphisms in the IGF1R and IGFBP3 genes may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status |
|
association of a 6-SNP IGF1R haplotype with spontaneous preterm birth in the fetuses |
| 
|
| Candidate gene
| for low birth weight, insuline resistance and type II diabetes |
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | endocrine | adrenal | |
| target for future therapeutic approaches in adrenal neoplasia |
| | |