| 1 | IGF1R, IRS1
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| IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.
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| Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI.
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| Elife 7. pii: e32893. doi: 10.7554/eLife.32893.
2018
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| 2 | BCL2L10, ESYT2, IGF1R, UBQLN1
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| The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.
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| Kurlawala Z, Shah PP, Shah C, Beverly LJ.
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| J Cell Biochem 118(8):2261-2270. doi: 10.1002/jcb.25880. Epub 2017 Apr 25. 2017
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| 3 | DIPK2A, IGF1R
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| HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.
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| Bareja A, Hodgkinson CP, Payne AJ, Pratt RE, Dzau VJ.
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| Biochem J. Feb 20;474(5):771-780. doi: 10.1042/BCJ20160976 2017
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| 4 | ESR1, IGF1R, PDZK1
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| PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.
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| Kim H, Abd Elmageed ZY, Ju J, Naura AS, Abdel-Mageed AB, Varughese S, Paul D, Alahari S, Catling A, Kim JG, Boulares AH.
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| Mol Med 19:253-62. doi: 10.2119/molmed.2011.00001.
2013
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| 5 | CAMP, IGF1R
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| Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.
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| Girnita A, Zheng H, Grönberg A, Girnita L, Ståhle M.
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| Oncogene 31(3):352-65. doi: 10.1038/onc.2011.239. Epub 2011 Jun 20.
2012
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| 6 | DEL15QD, IGF1R
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| IGF1R variants associated with isolated single suture craniosynostosis.
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| Cunningham ML, Horst JA, Rieder MJ, Hing AV, Stanaway IB, Park SS, Samudrala R, Speltz ML.
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| Am J Med Genet A 155(1):91-7. doi: 10.1002/ajmg.a.33781.PMID: 21204214 2011
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| 7 | IGF1R
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| Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.
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| Haataja R, Karjalainen MK, Luukkonen A, Teramo K, Puttonen H, Ojaniemi M, Varilo T, Chaudhari BP, Plunkett J, Murray JC, McCarroll SA, Peltonen L, Muglia LJ, Palotie A, Hallman M.
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| PLoS Genet 7(2):e1001293.
2011
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| 8 | DEL15Q26, IGF1R
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| Short stature due to 15q26 microdeletion involving IGF1R: Report of an additional case and review of the literature.
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| Rudaks LI, Nicholl JK, Bratkovic D, Barnett CP.
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| Am J Med Genet A 155(12):3139-43. doi: 10.1002/ajmg.a.34310. Epub 2011 Nov 7. No abstract available.
2011
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| 9 | IGF1R
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| A heterozygous mutation of the insulin-like growth factor-I receptor causes retention of the nascent protein in the endoplasmic reticulum and results in intrauterine and postnatal growth retardation.
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| Wallborn T, Wüller S, Klammt J, Kruis T, Kratzsch J, Schmidt G, Schlicke M, Müller E, van de Leur HS, Kiess W, Pfäffle R.
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| J Clin Endocrinol Metab 95(5):2316-24. Epub 2010 Mar 31.PMID: 20357178 2010
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| 10 | DEL9P, DMRT1, DMRT2, DUP15QD, IGF1R, SRA2
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| A de novo unbalanced translocation leading to partial monosomy 9p23-pter and partial trisomy 15q25.3-qter associated with 46,XY complete gonadal dysgenesis, tall stature and mental retardation.
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| Argyriou L, Hiort O, Meinecke P, Wünsch L, Volleth M, Hinrichs F, Caliebe A, Gillessen-Kaesbach G.
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| Clin Dysmorphol 19(4):190-4.PMID: 20671549 2010
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| 11 | ASMC15, DUP15QD, IGF1R
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| 15q overgrowth syndrome: A newly recognized phenotype associated with overgrowth, learning difficulties, characteristic facial appearance, renal anomalies and increased dosage of distal chromosome 15q.
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| Tatton-Brown K, Pilz DT, Orstavik KH, Patton M, Barber JC, Collinson MN, Maloney VK, Huang S, Crolla JA, Marks K, Ormerod E, Thompson P, Nawaz Z, Lese-Martin C, Tomkins S, Waits P, Rahman N, McEntagart M.
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| Am J Med Genet A 149A(2):147-54.
2009
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| 12 | IGF1R
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| Insulin-like growth factor-1 receptor activation prevents high glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis.
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| Li Y, Wu H, Khardori R, Song YH, Lu YW, Geng YJ.
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| Biochem Biophys Res Commun 384(2):259-64. Epub 2009 May 4.
2009
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| 13 | IGF1R, PTK2
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| Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor.
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| Andersson S, D'Arcy P, Larsson O, Sehat B.
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| Biochem Biophys Res Commun 387(1):36-41. Epub 2009 Jun 21.
2009
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| 14 | IGF1, IGF1R
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| Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.
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| Fang P, Schwartz ID, Johnson BD, Derr MA, Roberts CT Jr, Hwa V, Rosenfeld RG.
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| J Clin Endocrinol Metab 94(5):1740-7. Epub 2009 Feb 24.
2009
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| 15 | IGF1R, PTK2
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| Targeting of the protein interaction site between FAK and IGF-1R.
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| Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN.
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| Biochem Biophys Res Commun 388(2):301-5. Epub 2009 Aug 5.PMID: 19664602 2009
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| 16 | IGF1R, INSR
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| Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.
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| Pitetti JL, Torre D, Conne B, Papaioannou MD, Cederroth CR, Xuan S, Kahn R, Parada LF, Vassalli JD, Efstratiadis A, Nef S.
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| Sex Dev 3(5):264-72. Epub 2009 Oct 23.PMID: 19851056 2009
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| 17 | GLP2R, IGF1R
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| Synergistic effect of glucagon-like peptide 2 (GLP-2) and of key growth factors on the proliferation of cultured rat astrocytes. Evidence for reciprocal upregulation of the mRNAs for GLP-2 and IGF-I receptors.
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| Velázquez E, Blázquez E, Ruiz-Albusac JM.
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| Mol Neurobiol 40(2):183-93. Epub 2009 Aug 13.
2009
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| 18 | SS18, SSX1, SSX2, IGF1R
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| Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
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| Tšrnkvist M, Natalishvili N, Xie Y, Girnita A, D'Arcy P, Brodin B, Axelson M, Girnita L.
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| Biochem Biophys Res Commun 368(3):793-800. Epub 2008 Feb 11. 2008
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| 19 | DEL15QD, IGF1R
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| Drayer's syndrome of mental retardation, microcephaly, short stature and absent phalanges is caused by a recurrent deletion of chromosome 15(q26.2-->qter).
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| Rump P, Dijkhuizen T, Sikkema-Raddatz B, Lemmink HH, Vos YJ, Verheij JB, van Ravenswaaij CM.
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| Clin Genet 74(5):455-62. Epub 2008 Jul 21.
2008
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| 20 | DEL15QD, IGF1R
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| Successful long-term growth hormone therapy in a girl with haploinsufficiency of the insulin-like growth factor-I receptor due to a terminal 15q26.2->qter deletion detected by multiplex ligation probe amplification.
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| Walenkamp MJ, de Muinck Keizer-Schrama SM, de Mos M, Kalf ME, van Duyvenvoorde HA, Boot AM, Kant SG, White SJ, Losekoot M, Den Dunnen JT, Karperien M, Wit JM.
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| J Clin Endocrinol Metab 93(6):2421-5. Epub 2008 Mar 18.
2008
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| 21 | HOXA9, IGF1R
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| HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.
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| Whelan JT, Ludwig DL, Bertrand FE.
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| Leukemia 22(6):1161-9. Epub 2008 Mar 13.PMID: 18337761 2008
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| 22 | IGF1R, DUP15QD
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| Tall stature and duplication of the insulin-like growth factor I receptor gene.
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| Kant SG, Kriek M, Walenkamp MJ, Hansson KB, van Rhijn A, Clayton-Smith J, Wit JM, Breuning MH.
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| Eur J Med Genet 50(1):1-10. Epub 2006 Sep 14. 2007
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| 23 | ADCYAP1R1,IGF1R
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| PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons.
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| Delcourt N, Thouvenot E, Chanrion B, Galeotti N, Jouin P, Bockaert J, Marin P.
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| EMBO J 26(6):1542-51. Epub 2007 Mar 1. 2007
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| 24 | IGFALS, IGF1R, IGFBP3, IGF1
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| Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.
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| Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W.
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| Breast Cancer Res Treat 104(3):309-19. Epub 2006 Oct 25. 2007
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| 25 | IGF1R
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| Overexpression of the insulin-like growth factor I receptor in human pheochromocytomas.
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| Fottner C, Minnemann T, Kalmbach S, Weber MM.
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| J Mol Endocrinol 36(2):279-87. 2006
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| 26 | CD44, IGF1R
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| The IGFI receptor gene: a molecular target for disrupted transcription factors
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| Werner H, Roberts CT Jr.
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| Genes Chromosomes Cancer 36(2):113-20. Review. 2003
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| 27 | IGF1R, MAP3K5
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| Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
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| Galvan V, Logvinova A, Sperandio S, Ichijo H, Bredesen DE.
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| J Biol Chem 278(15):13325-32. Epub 2003 Jan 28. 2003
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| 28 | IGF1R, DEL15QD, DUP15QD
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| Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.
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| Okubo Y, Siddle K, Firth H, O'Rahilly S, Wilson LC, Willatt L, Fukushima T, Takahashi S, Petry CJ, Saukkonen T, Stanhope R, Dunger DB.
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| J Clin Endocrinol Metab 88(12):5981-8. 2003
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| 29 | IGF1R, DEL15QD
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| IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation.
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| Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D, Pfaffle R, Raile K, Seidel B, Smith RJ, Chernausek SD; Intrauterine Growth Retardation (IUGR) Study Group.
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| N Engl J Med 349(23):2211-22. 2003
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| 30 | DUP15QD, IGF1R
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| Postnatal overgrowth by 15q-trisomy and intrauterine growth retardation by 15q-monosomy due to familial translocation t(13;15): dosage effect of IGF1R?
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| Nagai T, Shimokawa O, Harada N, Sakazume S, Ohashi H, Matsumoto N, Obata K, Yoshino A, Murakami N, Murai T, Sakuta R, Niikawa N.
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| Am J Med Genet 113(2):173-7. 2002
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| 31 | DUP15QD, IGF1R
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| Overgrowth and trisomy 15q26.1-qter including the IGF1 receptor gene: report of two families and review of the literature.
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| Faivre L, Gosset P, Cormier-Daire V, Odent S, Amiel J, Giurgea I, Nassogne MC, Pasquier L, Munnich A, Romana S, Prieur M, Vekemans M, De Blois MC, Turleau C.
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| Eur J Hum Genet 10(11):699-706. 2002
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| 32 | IGF1R
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| Regulation of insulin-like growth factor-I receptor gene expression by tumor necrosis factor-alpha and interferon-gamma.
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| Shalita-Chesner M, Katz J, Shemer J, Werner H.
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| Mol Cell Endocrinol 176(1-2):1-12. 2001
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| 33 | IGF1R
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| Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein.
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| Ayalon D, Glaser T, Werner H.
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| Growth Horm IGF Res 11(5):289-97. 2001
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| 34 | AKT1, AKT2, IGF1, IGF1R
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| Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.
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| Kulik G, et al.
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| Mol Cell Biol 18(11):6711-8. 1998
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| 35 | SRS7, SRS17, SRSX, DEL15QD, IGF1R
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| Lack of hemizygosity for the insulin-like growth factor I receptor gene in a quantitative study of 33 Silver Russell syndrome probands and their families.
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| Abu-Amero S, Price S, Wakeling E, Stanier P, Trembath R, Preece MA, Moore GE.
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| Eur J Hum Genet 5(4):235-41. 1997
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| 36 | IGF1R
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| Insulin-like growth factor I receptor expression and function in fibroblasts from two patients with deletion of the distal long arm of chromosome 15.
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| Siebler T, et al.
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| J Clin Endocrinol Metab 80 : 3447-3457. 1995
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| 37 | IGF1R
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| Hemizygosity at the insulin-like growth factor 1 receptor (IGF1R) locus and growth failure in the ring chromosome 15 syndrome.
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| Peoples R, et al.
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| Cytogenet Cell Genet 70 : 228-234. 1995
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| 38 | IGF1R
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| Trinucleotide repeat polymorphism at the human insulin-like growth factor I receptor gene (IGF1R).
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| Meloni R, et al.
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| Nucleic Acids Res 20 : 1427. 1992
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| 39 | GABRB1, FCGR3B, CD247, DRD2, CD4, IGF1R
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| Genetic mapping of six human genes.
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| Dean M, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1853. 1991
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| 40 | DEL15QD, IGF1R
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| An infant with deletion of the distal long arm of chromosome 15 (q26.1----qter) and loss of insulin-like growth factor 1 receptor gene.
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| Roback EW, Barakat AJ, Dev VG, Mbikay M, Chretien M, Butler MG.
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| Am J Med Genet 38(1):74-9. 1991
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| 41 | PRKCA, IGF1R, PRKCG
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| Chromosomal mapping of genes involved in growth control.
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| Francke U, et al.
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| Cold Spring Harbor Symp Quant Biol 51 : 855-866. 1986
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| 42 | IGF1R
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| Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
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| Ullrich A, et al.
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| EMBO J 5 : 2503-2512. 1986
|