pre- and post-natal growth retardation, variable mental retardation, microcephaly, facial anomalies including relative micrognathia and triangular facies and small hands with brachymesophalangism
contiguous gene syndrome
growth retardation is likely related to the loss of one copy of the IGF1R gene and heart malformations to haploinsufficiency of NR2F2 gene, PMID: 21172461
some patients may exhibit some phenotypic characteristics of Silver-Russel syndrome. Heart malformations could be limited to deletions including the NR2F2 gene ~6.6 Mb of 15qtel. Congenital diaphragmatic hernias are observed in del15q26.1q26.2. See DIH1 for CDH-heart-kidney association.