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FLASH GENE
Symbol IFIT1 contributors: mct - updated : 23-08-2014
HGNC name interferon-induced protein with tetratricopeptide repeats 1
HGNC id 5407
Location 10q23.31      Physical location : 91.152.321 - 91.163.742
Synonym name
  • IFN-stimulated gene 56
    • Synonym symbol(s) G10P1, IFI56, IFI-56, IFNAI1, RNM561, GARG-16, ISG56, RNM561
    DNA
    TYPE functioning gene
    STRUCTURE 11.42 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D10S579 - D10S215 - D10S1765 - D10S541 - D10S1571 ,(IFIT2 - IFIT3 ) - D10S1442 - D10S1739 - IFIT1 - D10S1753 - D10S536 - D10S564 - D10S1755 - IDE ,D10S583 - D10S185 - D10S200 ,PDE6C ,RBP4 RBP4 - qter
    Authors Gray (97), De Veer (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1690 55.3 478 - Gravilov
    2 - 1876 56 478 - Gravilov
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Amphiphilic
    STRUCTURE
    motifs/domains
  • ten tetratricopeptide repeats (TPR) made of two interacting amphipathic alpha helices named domains A and D
    • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFI family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • virus-induced protein associated with TMEM173, an adapter protein involved in virus-triggered induction of type I IFNs
  • mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses
  • antiviral protein that recognizes 5prime-triphosphate RNA, antagonizing viruses by sequestering specific viral nucleic acids
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFIT1 and IFIT2 contribute significantly to the regulation of HBV replication, likely at both transcriptional and posttranscriptional steps
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between IFIT1 and eukaryotic elongation factor-1A (EEF1A1)
  • IFIT1 bound PPP-RNA with nanomolar affinity and required the arginine at position 187 in a highly charged C-terminal groove of the protein
  • can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA
  • binding to PPP-RNA is critical for the antiviral activity of IFIT1
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
  • more IRF8 bound to the IFN-stimulated response element of the IFIT1 gene than to those of the IFIT2 and the IFIT3 genes
    • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interleukin 1,retinoic acid,viral infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS