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FLASH GENE

Symbol

LIN7B

contributors: - updated : 26-08-2005

HGNC name	lin-7 homolog B (C. elegans)
HGNC id	17788

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.3      Physical location : 49.617.617 - 49.621.716
Synonym name	likely ortholog of mouse lin 7 homolog b (C. elegans)
	Lin-7b protein
	mammalian LIN-7 protein 2
Synonym symbol(s)	VELI2, LIN-7B, MALS-2

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex       brain hindbrain cerebellum       brain diencephalon hypothalamus       brain hindbrain medulla oblongata       brain basal nuclei striatum     Olfactory olfactory bulb

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PDZ domain

mono polymer

heteromer , trimer

HOMOLOGY

interspecies

homolog to C.elegans LIN-7

Homologene

FAMILY

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
text	localizing in synapses

basic FUNCTION

involved in regulation of synaptic function and synapse assembly

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

nervous system , exocytosis transport , cellular trafficking transport

PATHWAY

metabolism

signaling

neurotransmission

a component

heterotrimerizing with CASK,MINT1

INTERACTION

DNA

RNA

small molecule

protein	binding to proteins with E-T/S-R/X-V/I/L peptide sequences, like ionic channels and glutamate receptors, NR2B
	partner of BAIAP2 anchoring the actin-based membrane cytoskeleton at cell-cell contacts
	binding to GNG13

cell & other

REGULATION

induced by

Ca2+ calcineurin pathway

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS