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FLASH GENE

Symbol

INSIG2

contributors: mct - updated : 30-12-207

HGNC name	insulin induced gene 2
HGNC id	20452

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   . cholesterol metabolic aberrations, induced through disruption of either DHCR7 or INSIG1 and INSIG2 , result in osteoblast differentiation abnormalities

Susceptibility

to severe obesity to metabolic syndrome

Variant & Polymorphism SNP	significantly associated with obesity
	common INSIG2 variant rs9308762 was associated with poorer metabolic control and a greater sensitivity of trigylcerides to a modern dietary pattern

Candidate gene	putative positive prognostic biomarker for colon cancer prognosis
Marker
Therapy target

ANIMAL & CELL MODELS