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FLASH GENE
Symbol INSIG2 contributors: mct - updated : 30-12-207
HGNC name insulin induced gene 2
HGNC id 20452
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
. cholesterol metabolic aberrations, induced through disruption of either DHCR7 or INSIG1 and INSIG2 , result in osteoblast differentiation abnormalities
Susceptibility
  • to severe obesity
  • to metabolic syndrome
  • Variant & Polymorphism SNP
  • significantly associated with obesity
  • common INSIG2 variant rs9308762 was associated with poorer metabolic control and a greater sensitivity of trigylcerides to a modern dietary pattern
  • Candidate gene putative positive prognostic biomarker for colon cancer prognosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS