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FLASH GENE
Symbol INSIG2 contributors: mct - updated : 30-12-207
HGNC name insulin induced gene 2
HGNC id 20452
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2592 24.8 225 - 2002 12242332
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
nervousbraindiencephalon   
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane helices
  • HOMOLOGY
    interspecies homolog to murine Insig2 (96.9pc)
    homolog to rattus Insig2 (96.4pc)
    intraspecies homolog to INSIG1
    Homologene
    FAMILY
  • INSIG family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • negative regulator of cholesterol synthesis
  • involved in adipocyte metabolism and body weight regulation
  • in the presence of sterols, INSIG2 regulates lipid synthesis by blocking the proteolytic activation of SREBPs by SCAP and causing SREBPs to be retained in the ER (Yabe 2002)
  • essential role of INSIG1, INSIG2 proteins in the sterol homeostasis of enterocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with SCAP (to block export of sterol regulatory element-binding proteins)
  • sterol-induced ubiquitination and proteasomal degradation of reductase is dictated by the complex interplay of at least four proteins: INSIG1, INSIG2, AMFR, and RNF139
  • gluconeogenic enzyme PCK1 phosphorylates INSIG1/INSIG2 for lipogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    . cholesterol metabolic aberrations, induced through disruption of either DHCR7 or INSIG1 and INSIG2 , result in osteoblast differentiation abnormalities
    Susceptibility
  • to severe obesity
  • to metabolic syndrome
  • Variant & Polymorphism SNP
  • significantly associated with obesity
  • common INSIG2 variant rs9308762 was associated with poorer metabolic control and a greater sensitivity of trigylcerides to a modern dietary pattern
  • Candidate gene putative positive prognostic biomarker for colon cancer prognosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS