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FLASH GENE
Symbol AMOTL1 contributors: mct/pgu - updated : 23-05-2017
HGNC name angiomotin like 1
HGNC id 17811
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a polyglutamic acid repeat at the N-terminal region
  • a coiled-coil domain
  • a consensus motif for binding to PDZ domain at the C terrminus, C-terminal PDZ-binding motifs, required for the interactions with AMOT, AMOTL2, MPDZ, and INADL
    • HOMOLOGY
    interspecies homolog to murine Amotl1
    homolog to C.elegans C15B12.1
    intraspecies homolog to Leman coiled-coil protein
    Homologene
    FAMILY motins family, Amot/JEAP family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • peripheral membrane protein
  • apparent at TJs as well as apical membranes, and mostly co-localized with MPDZ
    • basic FUNCTION
  • involved in the control of paracellular permeability and maintain cell polarity
  • mediates the inhibitory effect of angiostatin on endothelial cell migration and tube formation
  • not only co-localizes with filamentous actin but also significantly modifies the architecture of the actin cytoskeleton
  • involved in actin-cytoskeleton-based processes, in part, via its interaction with a p80-angiomotin-containing complex and the actin cytoskeleton
  • AMOT appears to control the polarity of vascular tip cells whereas AMOTL1 mainly affects the stability of cell-cell junctions of the stalk cells
  • AMOTL1 and AMOTL2 can regulate YAP1 cytoplasm-to-nucleus translocation through direct protein-protein interaction, which can occur independent of YAP1 phosphorylation status
  • AMOT, AMOTL1 and AMOTL2, play critical roles in the Hippo pathway by regulating the subcellular localization of the co-activators YAP1 and TAZ
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component strucutural component of tight junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacing with MPDZ and INADL (interaction not necessarily responsible for their proper subcellular distribution
  • AMOTL1 and AMOTL2, are YAP1-associated proteins
  • AMOT and AMOTL1 interact with YAP1 via the first WW domain of YAP1
  • inhibits pro-apoptotic function of YAP1, whereas TJP2 enhances it
  • AMOTL1 is an essential effector of the CDH2 mediated endothelial/pericyte junctional complex
  • nuclear translocation of AMOTL1 islikely accompanied by YAP1 to promote cardiomyocyte proliferation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS