Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TAF15 | contributors: mct/npt/shn - updated : 04-11-2013 |
HGNC name | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa |
HGNC id | 11547 |
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EXPRESSION |
Type | widely |
tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | ortholog to taf15, Danio rerio |
ortholog to TAF15, Pan troglodytes | |
ortholog to Taf15, Mus musculus | |
ortholog to Taf15, Rattus norvegicus |
intraspecies | homolog to EWS,FUS,highly |
Homologene |
FAMILY |
CATEGORY | DNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm | |
intracellular,nucleus | |
text | the RGG repeat-containing C-terminus of TAF15 is responsible for the shuttling between the nucleus and the cytoplasm and the methylation of RGG repeats affects the subcellular localization of TAF15 (Jobert 2009) |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA | single stranded (ss) DNA |
RNA | RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function (Jobert 2009) |
specifically cleaved by caspases-3 and -7 (Alves 2009) |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene | Amyotrophic lateral sclerosis | |
Marker
Therapy target
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ANIMAL & CELL MODELS |
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