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FLASH GENE

Symbol

OLFM1

contributors: mct - updated : 28-03-2018

HGNC name	olfactomedin 1
HGNC id	17187

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function leads to defective olfaction and impaired female fertility ( tumoral     --low   in primary Colorectal cancer samples compared to adjacent non-cancerous tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a valuable biomarker for CRC patients (pMID: 27555280)
Therapy target
	System Type Disorder Pubmed neurology acquired   application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury cancer digestive colon may be a valuable therapeutic target for Colorectal cancer patients

ANIMAL & CELL MODELS

	Olfm1(-/-) female mice were previously reported to have reduced fertility
	olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant