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FLASH GENE
Symbol OLFM1 contributors: mct - updated : 28-03-2018
HGNC name olfactomedin 1
HGNC id 17187
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide
  • followed by a coiled-coil domain
  • an olfactomedin domain located in the C-terminal
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Olfm1
    homolog to C.elegans R166.5
    Homologene
    FAMILY olfactomedin domain-containing proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • OLFM1 staining was equally strong in the endoplasmic reticulum and the growth cones
    • basic FUNCTION
  • playing a role in regulating the production of neural crest by the neural tube
  • participates in neural progenitor maintenance, cell death in brain, and optic nerve arborization
  • localization of OLFM1 in the growth cones of neuronal cells suggests that it may play a role in axon growth and/or guidance
  • OLFM1 is a component of neuronal growth cones and is a novel soluble ligand of RTN4R, which regulates axonal outgrowth and axon bundle formation during brain development
  • is a highly expressed neuronal glycoprotein important for nervous system development
  • potential role for OLFM1 in clustering receptors to regulate signaling and sheds light on the conformation of several other olfactomedin domain family members
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
  • binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
  • is an endogenous antagonist of myelin-associated axon growth inhibitors
    • cell & other
    REGULATION
    Other stabilized by calcium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leads to defective olfaction and impaired female fertility (
    tumoral     --low  
    in primary Colorectal cancer samples compared to adjacent non-cancerous tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a valuable biomarker for CRC patients (pMID: 27555280)
    • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    application of OLFM1 or stimulation of its expression may be used to facilitate neuronal growth after axonal damage or injury
    cancerdigestivecolon
    may be a valuable therapeutic target for Colorectal cancer patients
    ANIMAL & CELL MODELS
  • Olfm1(-/-) female mice were previously reported to have reduced fertility
  • olfactory system was both structurally and functionally disturbed by the mutation in the Olfm1 gene which may contribute to the neonatal death and loss of body weight of Olfm1 mutant