basic FUNCTION
| mediating interactions with the nuclear envelope, and also tethering the nuclear envelope to chromatin |
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playing a major role in chromatin organization, DNA replication and RNA polymerase II-dependent gene expression |
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involved in nuclear stability, chromatin structure and gene expression |
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playing a key role in maintaining cellular resistance to deformation and in nucleo-cytoskeletal integrity |
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involved in the modulation of TGF-beta1 on collagen production, a marker of mesenchymal differentiation via nuclear phosphatases such as PPP2R3B |
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acting as inhibitors of adipocyte differentiation, possibly by affecting PPARgamma2 and insulin signaling |
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invovled in physiological aging |
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playing a critical role through the C-terminal globular lamin A/C region in nuclear structure (major contribution of abnormal assembly to the progeroid phenotype) |
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playing a role in normal cell senescence |
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involved in muscle differentiation |
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link between pre-lamin A processing and heterochromatin remodeling  |
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SUMO modification is important for normal LMNA function and implicate an involvement for altered sumoylation in the E203G/E203K lamin A cardiomyopathies  |
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importance of lamins in nuclear assembly and chromatin organization, and essential role in establishing and maintaining nuclear architecture  |
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might have a role in normal physiological cellular senescence  |
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LMNA and LBR sequentially tether peripheral heterochromatin and inversely regulate differentiation  |
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type V intermediate filament protein forming a filamentous meshwork, the lamina, underneath the inner nuclear membrane, for nuclear envelope structures organization and interphase chromatin anchoring  |
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component of the nuclear lamina that plays a critical role in the structural organization and function of the nucleus  |
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is part of the nuclear lamina, a meshwork of intermediate filaments underlying the inner nuclear membrane  |
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LMNA, TMPO and BANF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle  |
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LMNA localizes throughout the nucleus, where it associates with the chromatin-binding protein TMPO  |
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novel role of nucleoplasmic lamin A/C and TMPO in regulating euchromatin  |
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LMNA, LMNB1, LMNB2 not only constitute a scaffold for nuclear shape, rigidity and resistance to stress but also contribute to the organization of chromatin and chromosomal domains  |
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CNOT1-LMNA-Hedgehog signaling pathway axis exerts an oncogenic role in osteosarcoma progression  |
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remarkable role for LMNA and EMD as modulators of cytoskeletal and chromatin organization in the interphase nucleus  |
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LMNA, and EMD modulate subcellular distribution and organization of actin in cells  |
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LMNA and EMD modulate KLK10, SMAD2 and BCL2L12 expression levels as well as the spatial positions of gene loci in the interphase nucleus  |
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mislocalization of LINC complex proteins (SUN1, SUN2, LMNA, EMD, SYNE1) is a significant characteristic of cellular senescence phenotypes and may influence complex events at the nuclear membrane, including trafficking and heterochromatin attachment  |