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FLASH GENE
Symbol INSRR contributors: - updated : 07-12-2005
HGNC name insulin receptor-related receptor
HGNC id 6093
Location 1q21-q23      Physical location : 156.810.665 - 156.828.666
Synonym symbol(s) IRR
EC.number 2.7.1.112
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     21 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Endocrinepancreas    
 pancreasislet of Langerhans   
Urinarykidneytubuleconvoluted tubuledistal tubule 
 kidneynephron   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four fibronectin type-III domains
HOMOLOGY
Homologene
FAMILY TYR protein kinase family, insulin receptor subfamily
CATEGORY signaling hormone , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • probably binding an insulin related protein and having a tyrosine-protein kinase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility mutated in a region, involved in the susceptibility to type II non insulin dependent diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS