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FLASH GENE
Symbol DAP3 contributors: mct - updated : 31-08-2010
HGNC name death associated protein 3
HGNC id 2673
Location 1q22      Physical location : 155.658.873 - 155.708.317
Synonym name
  • mitochondrial 28s ribosomal protein s29
  • ionizing radiation resistance conferring protein
  • 28S ribosomal protein S29, mitochondrial
    • Synonym symbol(s) MRPS29, MRP10, DAP-3, MRP-S29, bMRP-10, MGC126058, MGC126059, DKFZp686G12159
    DNA
    TYPE functioning gene
    STRUCTURE 49.44 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1635 45.6 398 - Kissil (1999)
    13 - 1650 45.6 398 - Kissil (1999)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal targeting sequence to mitochondria with a putative cleavage site
  • potential P-loop nucleotide binding site
  • proline rich domain
  • a potential nuclear receptor-interacting domain (NR box)
    • HOMOLOGY
    interspecies homolog to murine Dap3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • pro-apoptotic protein located in the small subunit of the ribosome (Miller 2008)
  • detected in the cytosol and mitochondria fraction, but only a little in the nucleus fraction in the cells before anti-CD3 antibody stimulation (Tosa 2010)
    • basic FUNCTION
  • involved in mediating interferon-gamma induced cell death
  • potential regulatory function of mitochondrial DAP3 involved in cellular senescence (Murata 2006)
  • GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function (Jacques 2009)
  • mitochondrial ribosomal small subunit protein, which is a novel phosphorylated target (Miller 2008)
  • may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis (Jacques 2009)
  • responsible for regulating apoptosis induced by various stimuli (Harada 2010)
  • critical for anoikis induction (detachment of adherent epithelial cells from the extracellular matrix inducing apoptosis) (Li 2009)
  • critical for TCR-mediated induction of apoptosis at the downstream of NNR4A1 (Tosa 2010)
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of mitochondrial ribosome
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be interacting with MRPS27
  • interacting with the glycocorticoid receptor and enhancing its ligand-induced activiry
  • DAP3-binding protein termed death ligand signal enhancer (Harada 2010)
  • interferon-beta promoter stimulator 1 (MAVS) binds DAP3 and induces anoikis by caspase activation (Li 2009)
  • functionally associated with NR4A1 on TCR-mediated apoptosis (Tosa 2010)
    • cell & other
    REGULATION
    Other phosphorylated in an Akt-dependent manner, correlating with the suppression of DAP3-facilitated apoptosis in anoikis (Tosa 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS