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FLASH GENE
Symbol DAP3 contributors: mct - updated : 31-08-2010
HGNC name death associated protein 3
HGNC id 2673
Location 1q22      Physical location : 155.658.873 - 155.708.317
Synonym name
  • mitochondrial 28s ribosomal protein s29
  • ionizing radiation resistance conferring protein
  • 28S ribosomal protein S29, mitochondrial
  • Synonym symbol(s) MRPS29, MRP10, DAP-3, MRP-S29, bMRP-10, MGC126058, MGC126059, DKFZp686G12159
    DNA
    TYPE functioning gene
    STRUCTURE 49.44 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388704 1 similar to GBA protein MTX1P 1q21 metaxin 1 pseudogene GBA 1q21 glucosidase, beta; acid (includes glucosylceramidase) C1orf2 1q21 chromosome 1 open reading frame 2 SCAMP3 1q21 secretory carrier membrane protein 3 CLK2 1q21 CDC-like kinase 2 HCN3 1q22 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 PKLR 1q21 pyruvate kinase, liver and RBC FDPS 1q21.2 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) FLJ35976 1q22 hypothetical protein FLJ35976 RUSC1 1q21-q22 RUN and SH3 domain containing 1 ASH1L 1q21 ash1 (absent, small, or homeotic)-like (Drosophila) LOC284620 1q22 similar to CLDN6 MRPS29P1 1q21.3 mitochondrial ribosomal protein S29 pseudogene 1 FLJ10504 1q22 misato YAP 1q21.3 misato DAP3 1q21 death associated protein 3 LOC388705 1 similar to misato FLJ20203 1q22 hypothetical protein FLJ20203 SYT11 1q21.2 synaptotagmin XI RIT1 1q21.2 Ras-like without CAAX 1 KIAA0907 1q21 Ras-like without CAAX 1 GPR100 1q22 G protein-coupled receptor 100 ARHGEF2 1q11-q21 rho/rac guanine nucleotide exchange factor (GEF) 2 SSR2 1q21-q23 signal sequence receptor, beta (translocon-associated protein beta)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1635 45.6 398 - Kissil (1999)
    13 - 1650 45.6 398 - Kissil (1999)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal targeting sequence to mitochondria with a putative cleavage site
  • potential P-loop nucleotide binding site
  • proline rich domain
  • a potential nuclear receptor-interacting domain (NR box)
  • HOMOLOGY
    interspecies homolog to murine Dap3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • pro-apoptotic protein located in the small subunit of the ribosome (Miller 2008)
  • detected in the cytosol and mitochondria fraction, but only a little in the nucleus fraction in the cells before anti-CD3 antibody stimulation (Tosa 2010)
  • basic FUNCTION
  • involved in mediating interferon-gamma induced cell death
  • potential regulatory function of mitochondrial DAP3 involved in cellular senescence (Murata 2006)
  • GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function (Jacques 2009)
  • mitochondrial ribosomal small subunit protein, which is a novel phosphorylated target (Miller 2008)
  • may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis (Jacques 2009)
  • responsible for regulating apoptosis induced by various stimuli (Harada 2010)
  • critical for anoikis induction (detachment of adherent epithelial cells from the extracellular matrix inducing apoptosis) (Li 2009)
  • critical for TCR-mediated induction of apoptosis at the downstream of NNR4A1 (Tosa 2010)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of mitochondrial ribosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be interacting with MRPS27
  • interacting with the glycocorticoid receptor and enhancing its ligand-induced activiry
  • DAP3-binding protein termed death ligand signal enhancer (Harada 2010)
  • interferon-beta promoter stimulator 1 (MAVS) binds DAP3 and induces anoikis by caspase activation (Li 2009)
  • functionally associated with NR4A1 on TCR-mediated apoptosis (Tosa 2010)
  • cell & other
    REGULATION
    Other phosphorylated in an Akt-dependent manner, correlating with the suppression of DAP3-facilitated apoptosis in anoikis (Tosa 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS