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FLASH GENE
Symbol METAP2 contributors: - updated : 21-04-2006
HGNC name methionyl aminopeptidase 2
HGNC id 16672
Location 12q22-q23.2      Physical location : 95.867.821 - 95.909.611
Synonym name methionine aminopeptidase, eIF-2-associated p67
Synonym symbol(s) MNPEP
EC.number 3.4.11.18
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 liver    
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage germ cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal extended strings of basic and acidic residues
  • a C terminal catalytic domain
    • HOMOLOGY
    interspecies homolog to rattus P67 translational initiation factor
    Homologene
    FAMILY peptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • protecting the alpha subunit of eIF from inhibitory phosphorylation
  • removing the N-terminal MET residue from nascent proteins
  • playing a pivotal role in cell growth
    • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation
    protein, degradation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    cobalt Co2+
    protein
    cell & other
    REGULATION
    Other regulated by S100A4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene target for cancer therapy through reversible METAP2 inhibitors
    Marker
    Therapy target
    ANIMAL & CELL MODELS