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FLASH GENE
Symbol METAP2 contributors: - updated : 21-04-2006
HGNC name methionyl aminopeptidase 2
HGNC id 16672
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal extended strings of basic and acidic residues
  • a C terminal catalytic domain
    • HOMOLOGY
    interspecies homolog to rattus P67 translational initiation factor
    Homologene
    FAMILY peptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • protecting the alpha subunit of eIF from inhibitory phosphorylation
  • removing the N-terminal MET residue from nascent proteins
  • playing a pivotal role in cell growth
    • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation
    protein, degradation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    cobalt Co2+
    protein
    cell & other
    REGULATION
    Other regulated by S100A4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene target for cancer therapy through reversible METAP2 inhibitors
    Marker
    Therapy target
    ANIMAL & CELL MODELS