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FLASH GENE

Symbol

METAP2

contributors: - updated : 21-04-2006

HGNC name	methionyl aminopeptidase 2
HGNC id	16672

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus       highly   liver         Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum cardiac     Muscular striatum skeletal

cell lineage	germ cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal extended strings of basic and acidic residues
	a C terminal catalytic domain

HOMOLOGY

interspecies

homolog to rattus P67 translational initiation factor

Homologene

FAMILY

peptidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	protecting the alpha subunit of eIF from inhibitory phosphorylation
	removing the N-terminal MET residue from nascent proteins
	playing a pivotal role in cell growth

CELLULAR PROCESS	cell life, antiapoptosis
	protein, post translation
	protein, degradation
	protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	cobalt Co2+

protein

cell & other

REGULATION

Other

regulated by S100A4

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	target for cancer therapy through reversible METAP2 inhibitors
Marker
Therapy target

ANIMAL & CELL MODELS