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FLASH GENE
Symbol CARD11 contributors: mct/npt/pgu - updated : 09-12-2020
HGNC name caspase recruitment domain family, member 11
HGNC id 16393
ASSOCIATED DISORDERS
corresponding disease(s) PPBL , IMD11 , CADINS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
in diffuse large B cell lymphoma, that enhance activity and that are mostly found in the coiled-coil domain
tumoral somatic mutation      
frequently found in Non-Hodgkin lymphoma
tumoral germinal mutation     gain of function
CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymphoma (DLBCL)
tumoral     --over  
in cutaneous squamous cell carcinoma (cSCC)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • NCF2, SPPL3, PSMC1, CARD11, PSMB8 methylation could be the potential biomarkers for predicting brest cancer risk
  • Therapy target
    ANIMAL & CELL MODELS