| 1 | CARD11, NCF2, PSMB8, PSMC1, SPPL3
|
| Methylation of Immune-Related Genes in Peripheral Blood Leukocytes and Breast Cancer.
|
| Tian T, Fu J, Li D, Liu Y, Sun H, Wang X, Zhang X, Zhang D, Zheng T, Zhao Y, Pang D.
|
| Front Oncol. Feb 10;12:817565. doi: 10.3389/fonc.2022.817565. 2022
|
| 2 | CADINS, CARD11
|
| Multiplexed Functional Assessment of Genetic Variants in CARD11
|
| Meitlis I, Allenspach EJ, Bauman BM, Phan IQ, Dabbah G, Schmitt EG, Camp ND, Torgerson TR, Nickerson DA, Bamshad MJ, Hagin D, Luthers CR, Stinson JR, Gray J, Lundgren I, Church JA, Butte MJ, Jordan MB, Aceves SS, Schwartz DM, Milner JD, Schuval S, Skoda-Smith S, Cooper MA, Starita LM, Rawlings DJ, Snow AL, James RG.
|
| Am J Hum Genet Dec 3;107(6):1029-1043. doi: 10.1016/j.ajhg.2020.10.015. Epub 2020 Nov 16. 2020
|
| 3 | CARD11
|
| Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway.
|
| Wei Z, Zhang Y, Chen J, Hu Y, Jia P, Wang X, Zhao Q, Deng Y, Li N, Zang Y, Qin J, Wang X, Lu W.
|
| Sci Immunol. Nov 29;4(41):eaaw5618. doi: 10.1126/sciimmunol.aaw5618 2019
|
| 4 | CARD11
|
| Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling.
|
| Wang Z, Hutcherson SM, Yang C, Jattani RP, Tritapoe JM, Yang YK, Pomerantz JL.
|
| J Biol Chem. Oct 4;294(40):14648-14660. doi: 10.1074/jbc.RA119.009551. Epub 2019 Aug 7. 2019
|
| 5 | CARD11
|
| Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease.
|
| Bedsaul JR, Carter NM, Deibel KE, Hutcherson SM, Jones TA, Wang Z, Yang C, Yang YK, Pomerantz JL.
|
| Front Immunol. Sep 19;9:2105. doi: 10.3389/fimmu.2018.02105. eCollection 2018 2018
|
| 6 | CARD11, iMD11
|
| A Unique Heterozygous CARD11 Mutation Combines Pathogenic Features of Both Gain- and Loss-of-Function Patients in a Four-Generation Family.
|
| Desjardins M, Arjunaraja S, Stinson JR, Dorjbal B, Sundaresan J, Niemela J, Raffeld M, Matthews HF, Wang A, Angelus P, Su HC, Mazer BD, Snow AL.
|
| Front Immunol. Dec 12;9:2944. doi: 10.3389/fimmu.2018.02944. eCollection 2018 2018
|
| 7 | CADIS, CARD11
|
| Germline hypomorphic CARD11 mutations in severe atopic diseas
|
| Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR, Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, Voss K, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T, Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR, Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg N, Meffre E, Gelfand EW, Snow AL, Milner JD.
|
| Nat Genet. Aug;49(8):1192-1201. doi: 10.1038/ng.3898. Epub 2017 Jun 19. Erratum in: Nat Genet. 2017 Oct 27;49(11):1661 2017
|
| 8 | CARD11
|
| Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-kappaB and JNK activation.
|
| Knies N, Alankus B, Weilemann A, Tzankov A, Brunner K, Ruff T, Kremer M, Keller UB, Lenz G, Ruland J.
|
| Proc Natl Acad Sci U S A. Dec 29;112(52):E7230-8. doi: 10.1073/pnas.1507459112. Epub 2015 Dec 14. 2015
|
| 9 | CARD11
|
| Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-kappaB Regulation.
|
| Watt SA, Purdie KJ, den Breems NY, Dimon M, Arron ST, McHugh AT, Xue DJ, Dayal JH, Proby CM, Harwood CA, Leigh IM, South AP.
|
| Am J Pathol. Sep;185(9):2354-63. doi: 10.1016/j.ajpath.2015.05.018. Epub 2015 Jul 26 2015
|
| 10 | BCL10, CARD11, MALT1
|
| Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.
|
| Steinhardt JJ, Peroutka RJ, Mazan-Mamczarz K, Chen Q, Houng S, Robles C, Barth RN, DuBose J, Bruns B, Tesoriero R, Stein D, Fang R, Hanna N, Pasley J, Rodriguez C, Kligman MD, Bradley M, Rabin J, Shackelford S, Dai B, Landon AL, Scalea T, Livak F, Gartenhaus RB.
|
| Blood 124(25):3758-67. doi: 10.1182/blood-2014-07-589689. Epub 2014 Oct 15.
2014
|
| 11 | AIP, BCL10, CARD11, MALT1
|
| AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation.
|
| Schimmack G, Eitelhuber AC, Vincendeau M, Demski K, Shinohara H, Kurosaki T, Krappmann D.
|
| Cell Commun Signal 12:49. doi: 10.1186/s12964-014-0049-7.
2014
|
| 12 | CARD11, PPBL
|
| Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis.
|
| Brohl AS, Stinson JR, Su HC, Badgett T, Jennings CD, Sukumar G, Sindiri S, Wang W, Kardava L, Moir S, Dalgard CL, Moscow JA, Khan J, Snow AL.
|
| J Clin Immunol Clin Immunol. 2014 Oct 29. [Epub ahead of print]
2014
|
| 13 | AKT1, CARD11
|
| Phosphorylation of Carma1, but not Bcl10, by Akt regulates TCR/CD28-mediated NF-κB induction and cytokine production.
|
| Cheng J, Hamilton KS, Kane LP.
|
| Mol Immunol 59(1):110-6. doi: 10.1016/j.molimm.2014.01.011. Epub 2014 Feb 16.
2014
|
| 14 | CARD11, PLEKHO1
|
| CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1.
|
| Sakamoto T, Kobayashi M, Tada K, Shinohara M, Io K, Nagata K, Iwai F, Takiuchi Y, Arai Y, Yamashita K, Shindo K, Kadowaki N, Koyanagi Y, Takaori-Kondo A.
|
| PLoS One 9(1):e85762. doi: 10.1371/journal.pone.0085762. eCollection 2014.
2014
|
| 15 | BCL10, CARD11, MALT1
|
| Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
|
| Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H.
|
| Mol Cell 51(6):766-79. doi: 10.1016/j.molcel.2013.08.032.
2013
|
| 16 | CARD11, STUB1
|
| STUB1 is essential for T-cell activation by ubiquitinating CARMA1.
|
| Wang S, Li Y, Hu YH, Song R, Gao Y, Liu HY, Shu HB, Liu Y.
|
| Eur J Immunol 43(4):1034-41. doi: 10.1002/eji.201242554. Epub 2013 Feb 15.
2013
|
| 17 | CARD11, IMD11
|
| Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency.
|
| Greil J, Rausch T, Giese T, Bandapalli OR, Daniel V, Bekeredjian-Ding I, Stütz AM, Drees C, Roth S, Ruland J, Korbel JO, Kulozik AE.
|
| J Allergy Clin Immunol 131(5):1376-83.e3. doi: 10.1016/j.jaci.2013.02.012. Epub 2013 Apr 3.
2013
|
| 18 | CARD11, IMD11
|
| Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.
|
| Stepensky P, Keller B, Buchta M, Kienzler AK, Elpeleg O, Somech R, Cohen S, Shachar I, Miosge LA, Schlesier M, Fuchs I, Enders A, Eibel H, Grimbacher B, Warnatz K.
|
| J Allergy Clin Immunol 131(2):477-85.e1. doi: 10.1016/j.jaci.2012.11.050.
2013
|
| 19 | CARD11, SMO
|
| Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.
|
| Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, Agarwal NK, Vega F.
|
| Blood 121(23):4718-28. doi: 10.1182/blood-2012-12-470153. Epub 2013 Apr 30.
2013
|
| 20 | BCL10, CARD11
|
| Self-oligomerization of the CARD domain prevents complex formation in the CARMA1 signalosome.
|
| Park JH, Bae JY, Park HH.
|
| Int J Mol Med 31(5):1280-7. doi: 10.3892/ijmm.2013.1307. Epub 2013 Mar 19.
2013
|
| 21 | CARD11, PPBL
|
| Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
|
| Snow AL, Xiao W, Stinson JR, Lu W, Chaigne-Delalande B, Zheng L, Pittaluga S, Matthews HF, Schmitz R, Jhavar S, Kuchen S, Kardava L, Wang W, Lamborn IT, Jing H, Raffeld M, Moir S, Fleisher TA, Staudt LM, Su HC, Lenardo MJ.
|
| J Exp Med 209(12):2247-61. doi: 10.1084/jem.20120831. Epub 2012 Nov 5.
2012
|
| 22 | BCL10, CARD11, MALT1
|
| Structural insights into the assembly of CARMA1 and BCL10.
|
| Li S, Yang X, Shao J, Shen Y.
|
| PLoS One 7(8):e42775. doi: 10.1371/journal.pone.0042775. Epub 2012 Aug 3.
2012
|
| 23 | CARD11, FYB1, MAP3K7, SKAP1
|
| ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.
|
| Srivastava R, Burbach BJ, Mitchell JS, Pagán AJ, Shimizu Y.
|
| Mol Cell Biol 32(10):1908-17. doi: 10.1128/MCB.06541-11. Epub 2012 Mar 12. 2012
|
| 24 | CARD11
|
| T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.
|
| Molinero LL, Cubre A, Mora-Solano C, Wang Y, Alegre ML.
|
| Proc Natl Acad Sci U S A 109(45):18529-34. doi: 10.1073/pnas.1204557109. Epub 2012 Oct 22.
2012
|
| 25 | CARD11, PPP2R1A
|
| Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
|
| Eitelhuber AC, Warth S, Schimmack G, Düwel M, Hadian K, Demski K, Beisker W, Shinohara H, Kurosaki T, Heissmeyer V, Krappmann D.
|
| EMBO J 30(3):594-605. Epub 2010 Dec 14.
2011
|
| 26 | CARD11, PRKCQ, TNFRSF4, TRAF2
|
| Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
|
| So T, Soroosh P, Eun SY, Altman A, Croft M.
|
| Proc Natl Acad Sci U S A 108(7):2903-8. Epub 2011 Jan 31.
2011
|
| 27 | CARD11
|
| CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
|
| Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD.
|
| J Immunol 187(12):6197-207. doi: 10.4049/jimmunol.1101348. Epub 2011 Nov 9.
2011
|
| 28 | CARD11
|
| CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling.
|
| Lee AJ, Wu X, Cheng H, Zhou X, Cheng X, Sun SC.
|
| J Biol Chem 285(21):15696-703. Epub 2010 Mar 16.PMID: 20233721 2010
|
| 29 | CARD11
|
| Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.
|
| Lamason RL, McCully RR, Lew SM, Pomerantz JL.
|
| Biochemistry 49(38):8240-50.
2010
|
| 30 | CARD11, KIF13B
|
| The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN.
|
| Lamason RL, Kupfer A, Pomerantz JL.
|
| Mol Cell 40(5):798-809.
2010
|
| 31 | CARD11, MAP4K1
|
| Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
|
| Brenner D, Brechmann M, Röhling S, Tapernoux M, Mock T, Winter D, Lehmann WD, Kiefer F, Thome M, Krammer PH, Arnold R.
|
| Proc Natl Acad Sci U S A 106(34):14508-13. Epub 2009 Aug 11.PMID: 19706536 2009
|
| 32 | BCL10, CARD11, MALT1
|
| COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.
|
| Welteke V, Eitelhuber A, Düwel M, Schweitzer K, Naumann M, Krappmann D.
|
| EMBO Rep 10(6):642-8. Epub 2009 May 15.
2009
|
| 33 | CARD11
|
| Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.
|
| Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM.
|
| Science 319(5870):1676-9. Epub 2008 Mar 6. 2008
|
| 34 | BCL10, CARD11, MALT1
|
| The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
|
| McCully RR, Pomerantz JL.
|
| Mol Cell Biol 28(18):5668-86. Epub 2008 Jul 14.
2008
|
| 35 | CARD11, PPBL
|
| Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.
|
| Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM.
|
| Science 319(5870):1676-9. doi: 10.1126/science.1153629. Epub 2008 Mar 6.
2008
|
| 36 | CARD11
|
| CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation.
|
| Tanner MJ, Hanel W, Gaffen SL, Lin X.
|
| J Biol Chem 282(23):17141-7. Epub 2007 Apr 11. 2007
|
| 37 | CARD11
|
| A loss-of-function RNA interference screen for molecular targets in cancer.
|
| Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, Staudt LM.
|
| Nature 441(7089):106-10. Epub 2006 Mar 29. 2006
|
| 38 | CARD11, AKT1
|
| CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.
|
| Narayan P, Holt B, Tosti R, Kane LP.
|
| Mol Cell Biol 26(6):2327-36. 2006
|
| 39 | CARD10, CARD11, IKBKG
|
| Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.
|
| Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P.
|
| J Biol Chem 279(33):34323-31. Epub 2004 Jun 7. 2004
|
| 40 | CARD11
|
| The MAGUK family protein CARD11 is essential for lymphocyte activation.
|
| Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM.
|
| Immunity 18(6):763-75. 2003
|
| 41 | CARD11, FTSJ2
|
| Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.
|
| Ching YP, Zhou HJ, Yuan JG, Qiang BQ, Kung Hf HF, Jin DY.
|
| Genomics 79(1):2-6. 2002
|
| 42 | CARD11
|
| CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
|
| Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M.
|
| Nat Immunol 3(9):836-43. Epub 2002 Aug 05. 2002
|
| 43 | CARD11
|
| CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.
|
| Pomerantz JL, Denny EM, Baltimore D.
|
| EMBO J 21(19):5184-94. 2002
|
| 44 | BCL10, CARD11
|
| Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
|
| Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J.
|
| FEBS Lett 496(2-3):121-7. 2001
|
| 45 | CARD11, CARD14
|
| CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
|
| Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES.
|
| J Biol Chem 276(15):11877-82. 2001
|
| 46 | CARD10, CARD11, CARD14, CARD9
|
| Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
|
| Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J.
|
| J Biol Chem 276(24):21405-9. 2001
|
| 47 | BCL10, CARD10, CARD11, NLRC4, CARD14, NOD1, NOD2, CARD9, RIPK2
|
| Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation.
|
| Guiet C, Vito P.
|
| J Cell Biol 148(6):1131-40. 2000
|