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FLASH GENE
Symbol TEAD1 contributors: mct - updated : 06-03-2019
HGNC name TEA domain family member 1 (SV40 transcriptional enhancer factor)
HGNC id 11714
ASSOCIATED DISORDERS
corresponding disease(s) AA , AIC2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in hepatocellular carcinoma (HCC), and overexpression is involved in the growth and differentiation of HCC
tumoral        
suppressed multiple malignant phenotypes of osteosarcoma cells including cell proliferation, apoptosis resistance, and invasive potential
Susceptibility
Variant & Polymorphism
Candidate gene
  • prostate basal cell marker that correlate with poor clinical outcome in prostate cancer
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice overexpressing TEAD1 showed an age-dependent heart dysfunction
  • homozygous mutant mice embryos with a targeted disruption of the TEAD1 gene displayed abnormal heart development and died between embryonic days 11 and 12
  • murine Tead1-deficient cardiomyocytes have significantly decreased proliferation during the immediate postnatal period, when proliferation rate is normally high