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FLASH GENE
Symbol TEAD1 contributors: mct - updated : 06-03-2019
HGNC name TEA domain family member 1 (SV40 transcriptional enhancer factor)
HGNC id 11714
Corresponding disease
AA atrophia areata
AIC2 Aicardi syndrome 2
Location 11p15.3      Physical location : 12.695.968 - 12.966.283
Synonym name
  • SV40 transcriptional enhancer factor
  • transcriptional enhancer factor 1
  • protein GT-IIc
  • transcription factor 13
    • Synonym symbol(s) TEF1, TCF13, TEF-1, REF1, NTEF-1, TCF-13, TEAD-1, FLJ17970
    DNA
    TYPE functioning gene
    STRUCTURE 270.33 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - AMPD3 - D11S1346 - D11S688 - CSNK2A1P /D11S1315 - TEAD1 - D11S634 - D11S926 - PTH PTH - D11S1348 - CALCA - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 9433 - 426 - 1991 1851669
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
     parathyroid   highly
    Nervousbrain     Homo sapiens
    Reproductivefemale systemplacenta   
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    VisualMuller cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal DNA-binding TEA (TEF-1, TEC1, and AbaA) domain, conserved DNA-binding TEA domain, which binds to the MCAT cis-acting regulatory element
  • a C-terminal YAP-binding domain (YBD)
    • HOMOLOGY
    interspecies homolog to murine Tead1 (99.3pc)
    homolog to rattus Tead1 (99.5pc)
    Homologene
    FAMILY
  • TEA/ATTS domain family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • required for cardiac muscle specific genes expression
  • transduction of a variety of genes
  • playing essential roles in mediating biological functions of YAP1
  • transcriptional enhancer factor
  • directing the transactivation of several genes and in placental cells can act as a transcriptional repressor
  • inhibiting prolactin gene expression in uterine decidual cells, probably by interacting directly with other transcription factors
  • mediating activation of IFITM3 gene
  • mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling
  • proapoptotic function for TEAD1 and a non physiological cytoprotective effect for overexpressed TEAD1
  • is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers
  • central role for TEAD1 and YAP1 as signal-responsive regulators of multipotent pancreatic progenitors
  • TEAD1 was the major transcription factor of Hippo signaling pathway in osteosarcoma
  • TEAD1 promotes vascular smooth muscle cells (VSMCs) proliferation via transcriptional induction of SLC1A5, thereby activating MTOR signaling and promoting neointima formation
  • cell-autonomous TEAD1 function is required for normal cardiomyocyte proliferation
  • non-redundant critical requirement for TEAD1 in regulating cell cycle proteins and proliferation in cardiomyocytes in the perinatal heart
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • component in the Hippo pathway
  • YAP1-TEAD1 signaling induces mitochondrial biogenesis in endothelial cells (ECs) and stimulates angiogenesis through PPARGC1A
    • a component
    INTERACTION
    DNA binding specifically and cooperatively to the SPH and GT-IIC "enhansons" and activating transcription in a cell specific manner
  • binding to a TEAD1-binding site in the prolactin promoter
    • RNA
    small molecule
    protein
  • interacting with the MADS domain of SRF to coactivate the skeletal alpha-actinin promoter and with MEF2 factors (control of MEF2-dependent muscle-specific gene expression)
  • interacting with VGLL4 (modulates the activity of TEAD1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes)
  • interact with YAP1 (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription factors that activate proliferative and prosurvival gene expression programs
  • new, BIRC7-dependent, apoptotic role for TEAD1
  • TEAD1 may mediate muscle development through its target genes, MRPL21, NDUFA6 and CCNE1
  • regulation of NAIP by TEAD1/YAP1 is at the transcriptional level
  • TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with MYOCD binding to SRF
  • CIZ1 enhanced the interaction between YAP1 and TEAD1
  • TEAD1 is a novel regulator of PMP22 expression during development in concert with SOX10 and EGR2
  • acetylation-mediated, VGLL4-dependent switch that regulates TEAD1 stability and YAP1-TEAD1 activity
  • VGLL4 negatively regulates the TEAD1-YAP1 transcriptional complex and exerts its growth inhibitory control through its evolutionary conserved TDU2 domain at its C-terminus
  • NUP37 interacted with YAP1 and activated YAP1/TEAD1 signaling by enhancing the interaction between YAP1 and TEAD1
  • YAP1 binds to the TEA domain (TEAD1) transcription factor and controls angiogenesis
  • TEAD1 overexpression restores AQP4 expression, and both TEAD1 and AQP4 overexpression rescue migratory deficits in TEAD1-knockout cells, implicating a direct regulatory role for TEAD1-AQP4 in glioblastoma (GBM) migration
  • SLC1A5, a key glutamine transporter, is a novel TEAD1 target gene
  • transcriptional cofactor VGLL1 plays a prominent role in HPV early gene expression, dependent on its association with the transcription factor TEAD1
  • VGLL1 and VGLL3 interact with TEAD1 via a conserved amino acid motif called the TONDU domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AA , AIC2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC), and overexpression is involved in the growth and differentiation of HCC
    tumoral        
    suppressed multiple malignant phenotypes of osteosarcoma cells including cell proliferation, apoptosis resistance, and invasive potential
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • prostate basal cell marker that correlate with poor clinical outcome in prostate cancer
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice overexpressing TEAD1 showed an age-dependent heart dysfunction
  • homozygous mutant mice embryos with a targeted disruption of the TEAD1 gene displayed abnormal heart development and died between embryonic days 11 and 12
  • murine Tead1-deficient cardiomyocytes have significantly decreased proliferation during the immediate postnatal period, when proliferation rate is normally high