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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PLCB2

contributors: mct - updated : 11-07-2013

HGNC name	phospholipase C, beta 2
HGNC id	9055

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state constitutional       loss of function loss of PLCB2 and PLCB3 significantly impaired T cell migration

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
Therapy target
	System Type Disorder Pubmed cancer reproductive breast target for novel therapeutic breast cancer strategies

ANIMAL & CELL MODELS