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FLASH GENE
Symbol PLCB2 contributors: mct - updated : 11-07-2013
HGNC name phospholipase C, beta 2
HGNC id 9055
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytosolic
text
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes
    • basic FUNCTION
  • phospholipase C, beta 2, phosphatidylinositol specific
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli, critical to many chemoattractant elicited responses
  • in differentiating cells, the association of PLCB2 with actin, mediated by the PH domain, seems crucial for catalytic activity
  • plays a pivotal role in G-protein dependent signal transduction in platelets
  • PLCB2, PLCB3 play a critical role in T lymphocyte chemotaxis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds strongly to PLCdelta1(PLCD1) and inhibits its catalytic activity
  • activity of PLCD1 is controlled by the amount of bound PLCB2 that changes with displacement of the enzyme by heterotrimeric or small G proteins
  • WDR36 associated with PLCB2 and increased the interaction between GNAQ and PLCB2, but prevented sequestration of activated GNAQ by GRK2
  • interaction between SLC9A3R1 and CXCR2 or PLCB2 is PDZ motif-dependent
  • WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2
    • cell & other
    REGULATION
    activated by RAC1, that can activate PLCB2 to increase intracellular Ca(2+) levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state
    constitutional       loss of function
    loss of PLCB2 and PLCB3 significantly impaired T cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    target for novel therapeutic breast cancer strategies
    ANIMAL & CELL MODELS