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FLASH GENE

Symbol

PLCB2

contributors: mct - updated : 11-07-2013

HGNC name	phospholipase C, beta 2
HGNC id	9055

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	20.08 kb     32 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	presence of transcripts of two forms of PLCB2 generated by alternative splicing (PMID: 17497434)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004573 32 - 4694 NP_004564 - 1185 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434 PLCB2a PLCB2b - splicing - - 1170 . expressed in platelets at the protein level . higher cytoplasmic to nuclear ratio for PLCB2b compared to PLCB2a, suggesting that a great proportion of the total PLCB2a was in the nucleus relative to PLB2b 2007 17497434 lacking 15 AAs (corresponding to 864-878)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen           tonsils

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens Blood/Hematopoietic platelet Homo sapiens

cell lineage	predominantly, in hematopoietic cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
text	WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes

basic FUNCTION	phospholipase C, beta 2, phosphatidylinositol specific
	catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
	mediating a wide variety of cellular stimuli, critical to many chemoattractant elicited responses
	in differentiating cells, the association of PLCB2 with actin, mediated by the PH domain, seems crucial for catalytic activity
	plays a pivotal role in G-protein dependent signal transduction in platelets
	PLCB2, PLCB3 play a critical role in T lymphocyte chemotaxis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds strongly to PLCdelta1(PLCD1) and inhibits its catalytic activity
	activity of PLCD1 is controlled by the amount of bound PLCB2 that changes with displacement of the enzyme by heterotrimeric or small G proteins
	WDR36 associated with PLCB2 and increased the interaction between GNAQ and PLCB2, but prevented sequestration of activated GNAQ by GRK2
	interaction between SLC9A3R1 and CXCR2 or PLCB2 is PDZ motif-dependent
	WDR26 is required for PLCB2 translocation from the cytosol to the membrane in polarized leukocytes, and the translocation of PLCB2 was sufficient to cause partial activation of PLCB2

cell & other

REGULATION

activated by

RAC1, that can activate PLCB2 to increase intracellular Ca(2+) levels

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   suppression of PLCB2 plays an important role in switching M1 macrophages into an M2-like state constitutional       loss of function loss of PLCB2 and PLCB3 significantly impaired T cell migration

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers
Therapy target
	System Type Disorder Pubmed cancer reproductive breast target for novel therapeutic breast cancer strategies

ANIMAL & CELL MODELS