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FLASH GENE

Symbol

RARA

contributors: mct/ - updated : 13-06-2015

HGNC name	retinoic acid receptor, alpha
HGNC id	9864

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

RARA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       PML-RARalpha fusion alone can confer properties of self-renewal to committed hematopoietic progenitors before the onset of acute promyelocytic leukemia tumoral fusion       STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding tumoral fusion       fusion partner of BCOR in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia tumoral fusion       FIP1L1-RARA plays a pivotal role in its homodimerization and transcriptional repressor activity, contributingto the pathogenesis of distinct types of leukemia

Susceptibility

to obesity to meningomyelocele (MM)

Variant & Polymorphism SNP	rs12051734 conferred a protective effect for MM susceptibility (MID: 21254357)

Candidate gene	for isolated cleft lip/palate
Marker
Therapy target	PML-RARA degradation or therapy-triggered degradation of oncoproteins could be a general strategy to eradicate cancer stem cells

ANIMAL & CELL MODELS