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GENATLAS PHENOTYPE

last update : 5/09/2006

Symbol	RARA
Location	17q21.2
Name	acute promyelocytic leukemia or myeloid leukemia (APL)
Corresponding gene	RARA
Other symbol(s)	APL
Main clinical features	common breakpoints in translocation t (15;17) clustered in RARA second intron (see PML), in translocation t(11;17) (see ZNF145), in translocation t(5;17), and others
Genetic determination
Function/system disorder	hematology
Type	malignancy

Gene product

Name	chimeric fusion protein in translocation t(15;17) 5'-PML-RARA-3',in translocation t(5;17) (see NPM1),in translocation t(11;17) (see NUMA1)

Remark(s)