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GENATLAS PHENOTYPE
last update : 5/09/2006
Symbol RARA
Location 17q21.2
Name acute promyelocytic leukemia or myeloid leukemia (APL)
Corresponding gene RARA
Other symbol(s) APL
Main clinical features
  • common breakpoints in translocation t (15;17) clustered in RARA second intron (see PML), in translocation t(11;17) (see ZNF145), in translocation t(5;17), and others
    • Genetic determination
    Function/system disorder hematology
    Type malignancy
    Gene product
    Name chimeric fusion protein in translocation t(15;17) 5'-PML-RARA-3',in translocation t(5;17) (see NPM1),in translocation t(11;17) (see NUMA1)
    Remark(s)