Citations for
1RARA, USP37, ZBTB16
The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Yang WC, Shih HM.
Oncogene 32(43):5167-75. doi: 10.1038/onc.2012.537. Epub 2012 Dec 3. 2013
2CEBPA, RARA, ZBTB16
RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.
Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T.
Proc Natl Acad Sci U S A 110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29. 2013
3RARA, UCP1
Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.
Murholm M, Isidor MS, Basse AL, Winther S, Sørensen C, Skovgaard-Petersen J, Nielsen MM, Hansen AS, Quistorff B, Hansen JB.
BMC Cell Biol 14:41. doi: 10.1186/1471-2121-14-41. 2013
4CACUL1, RARA
CAC1 negatively regulates RARα activity through cooperation with HDAC.
Moon M, Um SJ, Kim EJ.
Biochem Biophys Res Commun 427(1):41-6. doi: 10.1016/j.bbrc.2012.08.142. Epub 2012 Sep 11. 2012
5RARA, RARB, RARG
Association of retinoic acid receptor genes with meningomyelocele.
Tran PX, Au KS, Morrison AC, Fletcher JM, Ostermaier KK, Tyerman GH, Northrup H.
Birth Defects Res A Clin Mol Teratol 91(1):39-43. doi: 10.1002/bdra.20744. Epub 2010 Dec 1. 2011
6RARA, TRIM32
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
Sato T, Okumura F, Kano S, Kondo T, Ariga T, Hatakeyama S.
J Cell Sci 124(Pt 20):3492-502. doi: 10.1242/jcs.088799. Epub 2011 Oct 7. 2011
7CFLAR, PML, RARA
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F.
Blood 118(11):3107-18. doi: 10.1182/blood-2011-04-349670. Epub 2011 Jul 29. 2011
8RARA, TRIM24
Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition.
Tisserand J, Khetchoumian K, Thibault C, Dembélé D, Chambon P, Losson R.
J Biol Chem 286(38):33369-79. doi: 10.1074/jbc.M111.225680. Epub 2011 Jul 18. 2011
9RARA, TADA3
Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket.
Li CW, Ai N, Dinh GK, Welsh WJ, Chen JD.
Nucleic Acids Res 38(16):5291-303. Epub 2010 Apr 22. 2010
10BCOR, RARA
BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.
Yamamoto Y, Tsuzuki S, Tsuzuki M, Handa K, Inaguma Y, Emi N.
Blood 116(20):4274-83. Epub 2010 Aug 31. 2010
11BNIP1, RARA, RARG, TNIP1
Liganded RARalpha and RARgamma interact with but are repressed by TNIP1.
Gurevich I, Aneskievich BJ.
Biochem Biophys Res Commun 389(3):409-14. Epub 2009 Sep 2.PMID: 19732752 2009
12RARA
Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis.
Chung SS, Wang X, Wolgemuth DJ.
Development 136(12):2091-100.PMID: 19465599 2009
13PML, RARA
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A, Tenen DG, Gilliland DG.
Leukemia 23(8):1462-71. Epub 2009 Mar 26.PMID: 19322209 2009
14RARA, STAT5B
Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA.
Iwanaga E, Nakamura M, Nanri T, Kawakita T, Horikawa K, Mitsuya H, Asou N.
Eur J Haematol 83(5):499-501. Epub 2009 Jul 18. No abstract available. PMID: 19624718 2009
15PML, RARA
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de Thé H.
Nat Med 14(12):1333-42. Epub 2008 Nov 23. Erratum in: Nat Med. 2009 Jan;15(1):117. PMID: 19029980 2008
16RARA
The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production.
Dawson HD, Collins G, Pyle R, Key M, Taub DD.
BMC Immunol 9:16.PMID: 18416830 2008
17RARA, STAT5B
Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.
Kusakabe M, Suzukawa K, Nanmoku T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Ninomiya H, Nagasawa T.
Eur J Haematol 80(5):444-7. Epub 2008 Jan 23.PMID: 18221386 2008
18ABCC3, RARA, RXRA
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.
Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL.
Am J Physiol Gastrointest Liver Physiol 292(5):G1221-7. Epub 2007 Feb 1.PMID: 17272513 2007
19PML, RARA
Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH.
Han JY, Kim KE, Kim KH, Park JI, Kim JS.
Leuk Res 31(2):239-43. Epub 2006 Jun 21.PMID: 16797070 2007
20IGFBP3, RARA, RXRA
Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.
Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM, Baxter RC.
Arch Biochem Biophys 465(2):359-69. Epub 2007 Jun 26.PMID: 17644060 2007
21PRKAR1A, RARA
The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia.
Catalano A, Dawson MA, Somana K, Opat S, Schwarer A, Campbell LJ, Iland H.
Blood 110(12):4073-6. Epub 2007 Aug 21.PMID: 17712046 2007
22RARA, RARB, RARG
A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
Marinelli A, Bossi D, Pelicci PG, Minucci S.
Leukemia 21(4):647-50. Epub 2007 Jan 25. 2007
23PML, RARA
PML-RARalpha fusion gene transcripts and biological features in acute promyelocytic leukemia patients.
Melo RA, de Vasconcellos JF, Melo FC, Machado CG, Lacerda TM, Souto FR.
Clin Lab Haematol 28(2):126-9.PMID: 16630218 2006
24RARA
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Lou YR, Miettinen S, Kagechika H, Gronemeyer H, Tuohimaa P.
Biochem Biophys Res Commun 338(4):1973-81. Epub 2005 Nov 7. 2005
25KMT2A, RARA
Rearrangement of the MLL gene and a region proximal to the RARalpha gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21).
Dube S, Fetni R, Hazourli S, Champagne M, Lemieux N.
Cancer Genet Cytogenet 145(1):54-9. 2003
26RARA, STAT5B
Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
Dong S, Tweardy DJ.
Blood 99(8):2637-46. 2002
27RARA
Retinoic acid is a potent regulator of growth plate chondrogenesis.
De Luca F, Uyeda JA, Mericq V, Mancilla EE, Yanovski JA, Barnes KM, Zile MH, Baron J.
Endocrinology 141(1):346-53. 2000
28RARA, RUNX1T1
Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17).
Varella-Garcia M, et al.
Leuk Lymphoma 33(3-4):403-6. 1999
29ALK, PML, RARA
Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21.
Melnick A, Fruchtman S, Zelent A, Liu M, Huang Q, Boczkowska B, Calasanz M, Fernandez A, Licht JD, Najfeld V.
Leukemia 13(10):1534-8. 1999
30PML, RARA, ZBTB16
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP.
Nat Genet 18(2):126-35. 1998
31PML, RARA, ZBTB16
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG.
Nature 391(6669):815-8. 1998
32RARA
Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.
Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y, Fujimoto T, Kakizuka A, Konno T, Iinuma K.
Blood 92 : 374-382. 1998
33HDAC1, HDAC2, PML, RARA, ZBTB16
Role of the histone deacetylase complex in acute promyelocytic leukaemia.
Lin RJ, et al.
Nature 391 : 811-814. 1998
34ZBTB16, RARA
The RARalpha-PLZF chimera associated with acute promyelocytic leukemia has retained a sequence-specific DNA-binding domain.
Sitterlin D, et al.
Oncogene 14 : 1067-1074. 1997
35PML, RARA
A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RARalpha mutation.
Shao W, Benedetti L, Lamph WW, Nervi C, Miller WH Jr.
Blood 89(12):4282-9. 1997
36NUMA1, RARA
Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.
Wells RA, Catzavelos C, Kamel-Reid S.
Nat Genet 17(1):109-13. 1997
37RARA
Unbalanced translocation t(5;17) in an atypical acute promyelocytic leukemia.
Brunel V, et al.
Genes Chromosomes Cancer 14 : 307-312. 1995
38PML, RARA
Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.
Yoshida H, et al.
Genes Chromosomes Cancer 12 : 37-44. 1995
39PML, RARA
Molecular analysis of simple variant translocations in acute promyelocytic leukemia.
Borrow J, et al.
Genes Chromosomes Cancer 9 : 234-243. 1994
40KMT2A, RARA
A case of acute monocytic leukemia with t(11;17) involving a rearrangement of MLL-1 and a region proximal to the RARA gene.
Reeves BR, et al.
Cancer Genet Cytogenet 74 : 50-53. 1994
41PML, RARA
The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.
Doucas V, et al.
Proc Natl Acad Sci U S A 90 : 9345-9349. 1993
42TOP2A, RARA
Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia : expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus.
McPherson JP, et al.
Cancer Res 53 : 5885-5889. 1993
43PML, RARA
Delineation of translocation t(15;17) in acute promyelocytic leukemia by chromosomal in situ suppression hybridization.
Speicher MR, et al.
Leuk Res 17 : 359-364. 1993
44RARA, PML
Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia.
Chang KS, et al.
Mol Cell Biol 12 : 800-810. 1992
45PML, RARA
Expression pattern of the RARalpha-PML fusion gene in acute promyelocytic leukemia.
Alcalay M, et al.
Proc Natl Acad Sci U S A 89 : 4840-4844. 1992
46PML, RARA
Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction.
Biondi A, et al.
Blood 80 : 492-497. 1992
47RARA
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.
Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P.
EMBO J 11(2):629-42.PMID: 1311253 1992
48RARA, PML
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.
Alcalay M, et al.
Proc Natl Acad Sci U S A 88 : 1977-1981. 1991
49RARA, RARB, RARG
Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.
Mattei MG, et al.
Genomics 10 : 1061-1069. 1991
50RARA
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR-alpha with a novel putative transcription factor, PML.
Kakizuka A, et al.
Cell 66 : 663-674. 1991
51RARA
The PML-RAR-alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
ThŽ H de, et al.
Cell 66 : 675-684. 1991
52RARA
Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation.
Chen SJ, et al.
Blood 78 : 2696-2701. 1991
53PML, RARA
The T(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
ThŽ H de, et al.
Nature 347 : 558-561. 1990
54RARA
Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.
Borrow J, et al.
Science 250 : 1577-1580. 1990
55RARA
Cloning and characterization of the t(15;17) translocation breakpoint region in acute promyelocytic leukemia.
Lemons RS, et al.
Genes Chromosomes Cancer 2 : 79-87. 1990
56RARA
Mapping of chromosome 17 breakpoints in acute myeloid leukemias.
Longo L, et al.
Oncogene 5 : 1557-1563. 1990
57RARA, RARB
Identification of a second human retinoic acid receptor.
Brand N, et al.
Nature 332 : 850-853. 1988
58RARA
A PstI RFLP for the human retinoic acid receptor in 17q21.
Arveiler B, et al.
Nucleic Acids Res 16 : 6252. 1988
59RARA
A retinoic acid receptor cDNA probe (RAR2) identifies a moderately frequent RFLP on chromosome 17.
Bale AE, et al.
Nucleic Acids Res 16 : 7755. 1988
60RARA
Mapping of the human retinoic acid receptor to the q21 band of chromosome 17.
Mattei MG, et al.
Hum Genet 80 : 186-188. 1988
61RARA
A human retinoic acid receptor which belongs to the family of nuclear receptors.
Petkovich M, et al.
Nature 330 : 444-450. 1987
62MIC7, PML, RARA
Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia.
Sheer D, et al.
Proc Natl Acad Sci U S A 80 : 5007-5011. 1983