Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PEPD

contributors: npt/SGE - updated : 02-02-2010

HGNC name	peptidase D
HGNC id	8840

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	134.94 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000285 15 - 2019 NP_000276 - 493 - - NM_001166056 - - 1896 NP_001159528 - 452 - - NM_001166057 - - 1827 NP_001159529 - 429 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   stomach       highly Nervous brain       moderately Reproductive female system placenta     moderately   female system uterus cervix   moderately Skin/Tegument skin       moderately Urinary bladder       moderately   kidney       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP , MetalloP , Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to rattus Pepd (89.2pc)
	homolog to murine Pepd (88.6pc)

Homologene

FAMILY	peptidase M24B family
	eukaryotic-type prolidase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	homodimer that hydrolyzes dipetptides or tripeptides with a prolyl or hydroxyprolyl residue in the C-terminal position
	playing an important role in collagen metabolism (high level of iminoacids in collagen), may be rate limiting for the production of collagen
	acting as a metallocarboxypeptidase D
	may have a role in angiogenic signalling, because of its overexpression increasing HIF1A (Surazynski 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid , other

signaling

collagen catabolism

a component

acetylation

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mn2+ (2 ions per subunit)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PEPD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         increased serum prolidase activity may be associated with endometrial cancer and may be related to local invasion of endometrial cancer (Arioz 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	serum prolidase activity can accurately predict the degree and stage of all histological lesions in non-alcoholic fatty liver disease (Kayadibi 2009)
	serum prolidase activity is significantly associated with the presence and severity of coronary artery disease and elevated activity might be an independent predictor of coronary atherosclerosis (Yildiz 2008)
	the presence of atrial fibrillation in patients with severe mitral stenosis may be associated with the plasma prolidase activity, tissue and plasma oxidative parameters (Rabus 2008)
	an elevated pleural fluid and serum prolidase activity in patients with tuberculous (TB) pleurisy compared with non-TB pleurisy group (Ipcioglu 2008)
	serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy (Demirbag 2007)
Marker
Therapy target

ANIMAL & CELL MODELS