| basic FUNCTION
| required in the regulation of mitochondrial function |
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activating TP53 by phosphorylation in association with 14.3.3 proteins YWHA* |
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essential regulator of stress response and reactive oxygen species-induced DNA damage that is critical for hematopoietic stem cell self-renewal |
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activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway |
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involved in cellular responses to ionizing radiation (IR)-induced DNA damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1 |
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leading to cell cycle arrest and apoptosis |
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playing a role in the repair of oxidative damage to telomeric DNA and for maintaining telomeric integrity |
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playing a role in gonad and neurological functions |
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playing an important role in the prevention of both T and B cell malignancies |
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regulating TP53 stability and neuronal death, independently of CHK2 in response to DNA damage |
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promoting apoptosis and suppressing tumorigenesis in response to MYC overexpression (ATM-dependent response to this damage is critical for TP53 activation, apoptosis, and the suppression of tumor development) |
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exhibiting selective substrate specificity in response to different genotoxic agents |
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functioning directly in the repair of chromosomal DNA DSBs by maintaining DNA ends in repair complexes generated during lymphocyte antigen receptor gene assembly |
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have postreplication repair functions distinct from those of H2AX, but likely have independent functions that theoretically could synergize in DNA repair and maintenance of genomic integrity |
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ATM family checkpoint kinase, playing an important role in telomere elongation (preferentially associates with the shortest telomeres and stimulates their elongation by telomerase)  |
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with ATR control mitotic events in vertebrate cells by targeting CEP63 and centrosome dependent spindle assembly |
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insulin-responsive protein and a major upstream activator of AKT following insulin treatment |
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potentially involved in the development of insulin resistance through down-regulation of AKT activity |
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with ATR are required for recovery from replication-dependent DSBs and to regulate RAD51 foci formation |
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essential for IL6 secretion during oncogene-induced senescence and by damaged cells that bypass senescence) |
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ATM and TP53-associated ZNF420 are negative regulator of TP53-mediated apoptosis |
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controls stability and pro-apoptotic function of DYRK2 in response to DNA damage |
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essential role for ATM in the intracellular control of DYRK2 |
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prevents RNA polymerase II elongation-dependent chromatin decondensation at regions distal to DNA double-strand breaks |
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regulate oxidative stress-induced endothelial cell dysfunction and premature senescence |
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through an ATM/AKT1/TP53/CDKN1A-dependent signaling pathway mediates an instructive role in oxidative stress-induced endothelial dysfunction and premature senescence |
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ATM has a critical regulatory function in controlling DNA end-stability and error-prone DSB repair and MRE11A nuclease plays a major role in initiating microhomology-mediated end joining in cells, particularly in neuronal cells, which are post-mitotic |
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sensor of oxidative stress that activates compensatory signaling (including mitochondrial biogenesis) in response to ROS |
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required with ATR for accurate response to replication arrest crucial to preserve genome stability |
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important sensor of reactive oxygen species in human cells |
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may similarly regulate global cellular responses to oxidative stress |
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important to limit incorrect end utilization during classical non-homologous end joining ( |
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NHEJ1, ATM and H2AFX all have fundamental roles in processing and joining DNA ends during V(D)J recombination, but these roles have been masked by unanticipated functional redundancies |
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protects cells from ROS accumulation by stimulating NADPH production and promoting the synthesis of nucleotides required for the repair of DSBs (double strand breaks) |
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in the context of excessive DNA damage, ATM employs IKBKG and RIPK1 through autocrine TNF signaling to switch on cytokine production and caspase activation |
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phosphorylates MDC1 at Thr-98 following DNA damage, which promotes its oligomerization |
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sensor of cellular DNA damage, playing potentially through ATM-signaling pathway a role in regulating L1 retrotransposition |
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has a role in L1 retrotransposition in neuronal and nonneuronal cell types |
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dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability |
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is functional near telomeres and is involved in end protection at telomeric double-strand breaks (DSBs), but is not required for the extensive resection at telomeric DSBs |
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ATM-mediated phosphorylation has a role in the response to multiple types of genotoxic stress |
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NBN and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair |
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NBN and ATM collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner |
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is needed not only for the initiation but also for the completion of HR |
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