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GENATLAS PHENOTYPE

last update : 21/08/2006

Symbol	MTCL
Location	11q22.3
Name	mantle cell lymphoma
Corresponding gene	ATM
Main clinical features	lymphoma
Genetic determination	other
Related entries	TSG11F
Function/system disorder	hematology
Type	malignancy

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		acquired, somatic t(11;14)(q13;q32) is considered the cytogenetic hallmark of the disease
	deletion		somatic deletion of the 11q22-q23 region
various types		abnormal protein/loss of function	inactivation of both alleles of the ATM gene with deletion of one allele, point mutation in the other or two point mutations,consistently occuring secundary chromosome changes

Remark(s)