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References OMIM Gene GeneReviews HGMD HGNC
last update : 21/08/2006
Symbol MTCL
Location 11q22.3
Name mantle cell lymphoma
Corresponding gene ATM
Main clinical features lymphoma
Genetic determination other
Related entries TSG11F
Function/system disorder hematology
Type malignancy
Gene mutationChromosome rearrangementEffectComments
  translocation   acquired, somatic t(11;14)(q13;q32) is considered the cytogenetic hallmark of the disease
  deletion   somatic deletion of the 11q22-q23 region
various types   abnormal protein/loss of function inactivation of both alleles of the ATM gene with deletion of one allele, point mutation in the other or two point mutations,consistently occuring secundary chromosome changes