| 1 | ATM, ATP6V1A
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| ATM loss disrupts the autophagy-lysosomal pathway.
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| Cheng A, Tse KH, Chow HM, Gan Y, Song X, Ma F, Qian YXY, She W, Herrup K.
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| Autophagy Aug;17(8):1998-2010. doi: 10.1080/15548627.2020.1805860. Epub 2020 Aug 14 2021
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| 2 | ATM, PALB2
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| Inherited DNA-Repair Defects in Colorectal Cancer.
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| AlDubayan SH, Giannakis M, Moore ND, Han GC, Reardon B, Hamada T, Mu XJ, Nishihara R, Qian Z, Liu L, Yurgelun MB, Syngal S, Garraway LA, Ogino S, Fuchs CS, Van Allen EM.
|
| Am J Hum Genet 102(3):401-414. doi: 10.1016/j.ajhg.2018.01.018. Epub 2018 Feb 22.
2018
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| 3 | ATM, RSF1, SMARCA5
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| Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage.
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| Min S, Choi YW, Yun H, Jo S, Ji JH, Cho H.
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| Mol Cells 41(2):127-133. doi: 10.14348/molcells.2018.2244. Epub 2018 Jan 31.
2018
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| 4 | ATM, KDM2A
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| ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.
|
| Cao LL, Wei F, Du Y, Song B, Wang D, Shen C, Lu X, Cao Z, Yang Q, Gao Y, Wang L, Zhao Y, Wang H, Yang Y, Zhu WG.
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| Oncogene 35(3):402. doi: 10.1038/onc.2015.311. No abstract available.
2016
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| 5 | ATM, BCL2L1, PACS2
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| PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage.
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| Barroso-González J, Auclair S, Luan S, Thomas L, Atkins KM, Aslan JE, Thomas LL, Zhao J, Zhao Y, Thomas G.
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| Cell Death Differ 23(9):1448-57. doi: 10.1038/cdd.2016.23. Epub 2016 Mar 4.
2016
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| 6 | ATM, RAD51
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| Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation.
|
| Bakr A, Oing C, Köcher S, Borgmann K, Dornreiter I, Petersen C, Dikomey E, Mansour WY.
|
| Nucleic Acids Res 43(6):3154-66. doi: 10.1093/nar/gkv160.
2015
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| 7 | ATM, GIT2, MRE11
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| Nuclear GIT2 is an ATM substrate and promotes DNA repair.
|
| Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S.
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| Mol Cell Biol 35(7):1081-96. doi: 10.1128/MCB.01432-14.
2015
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| 8 | ATM, CHEK2
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| Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
|
| Chou WC, Hu LY, Hsiung CN, Shen CY.
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| Carcinogenesis 36(8):832-40. doi: 10.1093/carcin/bgv079. Epub 2015 May 29.
2015
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| 9 | ATM, BRAT1, NDFIP1
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| Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
|
| Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS.
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| J Biol Chem. Mar 13;290(11):7141-50. doi: 10.1074/jbc.M114.613687. Epub 2015 Jan 28. 2015
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| 10 | ATM, MEF2D
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| ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage.
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| Chan SF, Sances S, Brill LM, Okamoto S, Zaidi R, McKercher SR, Akhtar MW, Nakanishi N, Lipton SA.
|
| J Neurosci 34(13):4640-53. doi: 10.1523/JNEUROSCI.2510-12.2014.
2014
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| 11 | ATM, CROCC
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| The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.
|
| Lai WL, Hung WY, Ching YP.
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| Oncogene 33(45):5303-9. doi: 10.1038/onc.2013.481. Epub 2013 Nov 18.
2014
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| 12 | ATM, TCL1A
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| TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q.
|
| Garding A, Bhattacharya N, Haebe S, Müller F, Weichenhan D, Idler I, Ickstadt K, Stilgenbauer S, Mertens D.
|
| Haematologica 98(2):269-73. doi: 10.3324/haematol.2012.070623. Epub 2012 Aug 8.
2013
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| 13 | ATM
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| Ataxia telangiectasia presenting as dopa-responsive cervical dystonia.
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| Charlesworth G, Mohire MD, Schneider SA, Stamelou M, Wood NW, Bhatia KP.
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| Neurology 81(13):1148-51. doi: 10.1212/WNL.0b013e3182a55fa2. Epub 2013 Aug 14.
2013
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| 14 | ATM
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| The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
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| Shiloh Y, Ziv Y.
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| Nat Rev Mol Cell Biol 14(4):197-210. Review.
2013
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| 15 | ATM
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| ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.
|
| Alagoz M, Chiang SC, Sharma A, El-Khamisy SF.
|
| PLoS One 8(4):e58239. doi: 10.1371/journal.pone.0058239. Print 2013.
2013
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| 16 | ATM
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| The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
|
| Shiloh Y, Ziv Y.
|
| Nat Rev Mol Cell Biol 14(4):197-210. doi: 10.1038/nrm3546. Epub 2013 Mar 13. Review.
2013
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| 17 | ATM, DAXX
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| Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
|
| Tang J, Agrawal T, Cheng Q, Qu L, Brewer MD, Chen J, Yang X.
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| PLoS One 8(2):e55813. doi: 10.1371/journal.pone.0055813. Epub 2013 Feb 6. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/032b026 2013
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| 18 | ATM, NBN, NBS1
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| Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.
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| Rodrigues PM, Grigaravicius P, Remus M, Cavalheiro GR, Gomes AL, Rocha-Martins M, Frappart L, Reuss D, McKinnon PJ, von Deimling A, Martins RA, Frappart PO.
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| PLoS One 8(7):e69209. doi: 10.1371/journal.pone.0069209. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/b38f50e0-04b 2013
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| 19 | ATM, ATR, NBN, TOPBP1
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| NBS1 directly activates ATR independently of MRE11 and TOPBP1.
|
| Kobayashi M, Hayashi N, Takata M, Yamamoto K.
|
| Genes Cells 18(3):238-46. doi: 10.1111/gtc.12031. Epub 2013 Feb 1.
2013
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| 20 | ATM, NKX3-1
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| Functional activation of ATM by the prostate cancer suppressor NKX3.1.
|
| Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP.
|
| Cell Rep 4(3):516-29. doi: 10.1016/j.celrep.2013.06.039. Epub 2013 Jul 25.
2013
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| 21 | ATM, ATR, DDB2, XPC
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| NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.
|
| Ray A, Milum K, Battu A, Wani G, Wani AA.
|
| DNA Repair (Amst) 12(4):273-83. doi: 10.1016/j.dnarep.2013.01.003. Epub 2013 Feb 17.
2013
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| 22 | ATM, BRCA1, E2F1, RBBP8
|
| Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.
|
| Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A.
|
| Cell Physiol Biochem 30(3):596-608. doi: 10.1159/000341441. Epub 2012 Jul 27.
2012
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| 23 | ATM, PCNA
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| ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.
|
| Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ.
|
| J Biol Chem 287(15):12445-54. doi: 10.1074/jbc.M112.352310. Epub 2012 Feb 23.
2012
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| 24 | ATM, SATB1
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| ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
|
| Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T.
|
| PLoS One 7(12):e51786. doi: 10.1371/journal.pone.0051786. Epub 2012 Dec 10.
2012
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| 25 | ATM, CDC25C
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| ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.
|
| Thanasoula M, Escandell JM, Suwaki N, Tarsounas M.
|
| EMBO J 31(16):3398-410. doi: 10.1038/emboj.2012.191. Epub 2012 Jul 27.
2012
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| 26 | ATM
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| ATM mutations in patients with hereditary pancreatic cancer.
|
| Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, Goggins M, Vogelstein B, Papadopoulos N, Hruban RH, Kinzler KW, Klein AP.
|
| Cancer Discov 2(1):41-6. doi: 10.1158/2159-8290.CD-11-0194. Epub 2011 Dec 29.
2012
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| 27 | ATM, ATR, CCAR2
|
| DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.
|
| Zannini L, Buscemi G, Kim JE, Fontanella E, Delia D.
|
| J Mol Cell Biol 4(5):294-303. doi: 10.1093/jmcb/mjs035. Epub 2012 Jun 26.
2012
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| 28 | ATM, NBN, SKP2
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| Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.
|
| Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan X, Khanna KK, Jin J, Zeng YX, Lin HK.
|
| Mol Cell 46(3):351-61. doi: 10.1016/j.molcel.2012.02.018. Epub 2012 Mar 29.
2012
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| 29 | ATM, H2AFX, NHEJ1
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| ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
|
| Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.
|
| Nature 469(7329):250-4. Epub 2010 Dec 15.
2011
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| 30 | ATM
|
| Ataxia telangiectasia mutated influences cytochrome c oxidase activity.
|
| Patel AY, McDonald TM, Spears LD, Ching JK, Fisher JS.
|
| Biochem Biophys Res Commun 405(4):599-603. Epub 2011 Jan 23.
2011
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| 31 | ATM
|
| ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.
|
| Cosentino C, Grieco D, Costanzo V.
|
| EMBO J 30(3):546-55. Epub 2010 Dec 14.
2011
|
| 32 | ATM, IKBKG, RIPK1
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| NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling.
|
| Biton S, Ashkenazi A.
|
| Cell 145(1):92-103.
2011
|
| 33 | ATM, PNKP
|
| ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
|
| Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y.
|
| EMBO Rep 12(7):713-9. doi: 10.1038/embor.2011.96.
2011
|
| 34 | ATM, MDC1
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| Oligomerization of MDC1 protein is important for proper DNA damage response.
|
| Luo K, Yuan J, Lou Z.
|
| J Biol Chem 286(32):28192-9. Epub 2011 Jun 24.
2011
|
| 35 | AKT1, ATM, MRE11A, RNF168
|
| MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
|
| Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
|
| Cell Cycle 10(13):2218-32. Epub 2011 Jul 1.
2011
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| 36 | ATM
|
| Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
|
| Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH.
|
| Proc Natl Acad Sci U S A 108(51):20382-7. doi: 10.1073/pnas.1100273108. Epub 2011 Dec 9.
2011
|
| 37 | ATM, DYRK2, MDM2
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| ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
|
| Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K.
|
| J Biol Chem 285(7):4909-19. Epub 2009 Dec 4. 2010
|
| 38 | ATM, RNF168, RNF8, USP16
|
| ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.
|
| Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA.
|
| Cell 141(6):970-81.
2010
|
| 39 | ATM, ATR, RAD51, WRN
|
| ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
|
| Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P.
|
| EMBO J 29(18):3156-69. Epub 2010 Aug 27. 2010
|
| 40 | ATM
|
| Multiple roles of ATM in monitoring and maintaining DNA integrity.
|
| Derheimer FA, Kastan MB.
|
| FEBS Lett 584(17):3675-81. Epub 2010 May 24. Review.PMID: 20580718 2010
|
| 41 | ATM, ATR, TP53BP1
|
| Telomeres avoid end detection by severing the checkpoint signal transduction pathway.
|
| Carneiro T, Khair L, Reis CC, Borges V, Moser BA, Nakamura TM, Ferreira MG.
|
| Nature 467(7312):228-32. 2010
|
| 42 | ATM
|
| ATM activation by oxidative stress.
|
| Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT.
|
| Science 330(6003):517-21.
2010
|
| 43 | ATM
|
| Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence.
|
| Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R.
|
| J Biol Chem 285(38):29662-70. Epub 2010 Jul 16.
2010
|
| 44 | ATM, ZNF420
|
| Differential regulation of Apak by various DNA damage signals.
|
| Wang S, Tian C, Xiao T, Xing G, He F, Zhang L, Chen H.
|
| Mol Cell Biochem 333(1-2):181-7. Epub 2009 Jul 23. Erratum in: Mol Cell Biochem. 2010 Jan;333(1-2):189. Xiao, Tingtiang [corrected to Xiao, Tingt 2010
|
| 45 | ATM, ATMIN
|
| The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain.
|
| Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, Raivich G, Behrens A.
|
| J Biol Chem 285(49):38534-42. Epub 2010 Oct 2.
2010
|
| 46 | ATM
|
| ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks.
|
| Bennardo N, Stark JM.
|
| PLoS Genet 6(11):e1001194.
2010
|
| 47 | ATM, MAP3K7
|
| ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
|
| Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V.
|
| Mol Cell. 40(1):75-86. 2010
|
| 48 | ATM, MRE11A
|
| ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
|
| Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K.
|
| Cell Cycle 9(14):2866-77. Epub 2010 Jul 12.
2010
|
| 49 | ATM, MRE11, RAD50, TP53BP1
|
| 53BP1 promotes ATM activity through direct interactions with the MRN complex.
|
| Lee JH, Goodarzi AA, Jeggo PA, Paull TT.
|
| EMBO J 29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10.
2010
|
| 50 | ATM, CCND1
|
| ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation.
|
| Choo DW, Baek HJ, Motoyama N, Cho KH, Kim HS, Kim SS.
|
| Biochem Biophys Res Commun 378(4):847-50. Epub 2008 Dec 9.
2009
|
| 51 | ATM, ATR, CEP63
|
| An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.
|
| Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V.
|
| Nat Cell Biol 11(3):278-85. Epub 2009 Feb 1.
2009
|
| 52 | ATM, H2AFX, NBN
|
| Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.
|
| Kobayashi J, Tauchi H, Chen B, Bruma S, Tashiro S, Matsuura S, Tanimoto K, Chen DJ, Komatsu K.
|
| Biochem Biophys Res Commun 380(4):752-7. Epub 2009 Jan 23.
2009
|
| 53 | ATM
|
| Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
|
| Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.
|
| EMBO Rep 10(8):887-93. Epub 2009 Jun 26.
2009
|
| 54 | ATM, FMR1
|
| The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.
|
| Kumari D, Somma V, Nakamura AJ, Bonner WM, D'Ambrosio E, Usdin K.
|
| Nucleic Acids Res 37(13):4385-92. Epub 2009 May 21.
2009
|
| 55 | ATM
|
| Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer.
|
| Tavtigian SV, Oefner PJ, Babikyan D, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Byrnes GB, Chuang SC, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas A, Vallée MP, Voegele C, Webb PM, Whiteman DC; Australian Cancer Study; Breast Cancer Family Registries (BCFR); Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G.
|
| Am J Hum Genet 85(4):427-46. Epub 2009 Sep 24.
2009
|
| 56 | ATM, IL6
|
| Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
|
| Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.
|
| Nat Cell Biol 11(8):973-9. Epub 2009 Jul 13. Erratum in: Nat Cell Biol. 2009 Oct;11(10):1272. Dosage error in article text. PMID: 19597488 2009
|
| 57 | ATM, PRKDC, TDP1
|
| Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
|
| Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.
|
| EMBO J 28(23):3667-80. Epub 2009 Oct 22.PMID: 19851285 2009
|
| 58 | ATM, ATRX, RAD54B
|
| Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
|
| Kirshner M, Rathavs M, Nizan A, Essers J, Kanaar R, Shiloh Y, Barzilai A.
|
| DNA Repair (Amst) 8(2):253-61. Epub 2008 Dec 30. 2009
|
| 59 | ATM
|
| ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
|
| Brunet J, GutiŽrrez-Enr’quez S, Torres A, BŽrez V, SanjosŽ S, Galceran J, Izquierdo A, MenŽndez JA, Gumˆ J, Borrˆs J.
|
| Clin Genet 73(5):465-73. Epub 2008 Apr 2. 2008
|
| 60 | ATM, H2AFX
|
| Complementary functions of ATM and H2AX in development and suppression of genomic instability.
|
| Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW.
|
| Proc Natl Acad Sci U S A 105(27):9302-6. Epub 2008 Jul 1. 2008
|
| 61 | ATM, TNFSF4
|
| ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs.
|
| Smirnov DA, Cheung VG.
|
| Am J Hum Genet 83(2):243-53.
2008
|
| 62 | ATM, FOXO3
|
| Functional interaction between FOXO3a and ATM regulates DNA damage response.
|
| Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC.
|
| Nat Cell Biol 10(4):460-7. Epub 2008 Mar 16.
2008
|
| 63 | ATM
|
| ATM gene variants in patients with idiopathic perifoveal telangiectasia.
|
| Barbazetto IA, Room M, Yannuzzi NA, Barile GR, Merriam JE, Bardal AM, Freund KB, Yannuzzi LA, Allikmets R.
|
| Invest Ophthalmol Vis Sci 49(9):3806-11. Epub 2008 May 23.
2008
|
| 64 | ATM, FOXO3
|
| Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
|
| Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S.
|
| J Biol Chem 283(37):25692-705. Epub 2008 Apr 18.
2008
|
| 65 | ATF2, ATF5, ATM, KAT5
|
| Regulation of TIP60 by ATF2 modulates ATM activation.
|
| Bhoumik A, Singha N, O'Connell MJ, Ronai ZA.
|
| J Biol Chem 283(25):17605-14. Epub 2008 Apr 8. 2008
|
| 66 | APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
|
| Somatic mutations affect key pathways in lung adenocarcinoma.
|
| Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
|
| Nature 455(7216):1069-75.
2008
|
| 67 | ATM, ATR, CEP164
|
| Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
|
| Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY.
|
| Genes Dev 22(5):587-600. Epub 2008 Feb 18.PMID: 18283122 2008
|
| 68 | ATM
|
| A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
|
| Tang X, Hui ZG, Cui XL, Garg R, Kastan MB, Xu B.
|
| Mol Cell Biol 28(8):2559-66. Epub 2008 Feb 4.PMID: 18250156 2008
|
| 69 | ATM
|
| ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells.
|
| Halaby MJ, Hibma JC, He J, Yang DQ.
|
| Cell Signal 20(8):1555-63. Epub 2008 Apr 26.
2008
|
| 70 | ATM, C1QBP
|
| Identification of p32 as a novel substrate for ATM in heart.
|
| Kato H, Takashima S, Asano Y, Shintani Y, Yamazaki S, Seguchi O, Yamamoto H, Nakano A, Higo S, Ogai A, Minamino T, Kitakaze M, Hori M.
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| Biochem Biophys Res Commun 366(4):885-91. Epub 2007 Dec 10.
2008
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| 71 | ATM,H2AFX
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| Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
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| Tanaka T, Kajstura M, Halicka HD, Traganos F, Darzynkiewicz Z.
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| Cell Prolif 40(1):1-13. 2007
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| 72 | MRE11A, NBS1, ATM
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| The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
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| Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.
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| Nature 447(7141):218-21. Epub 2007 Apr 11. 2007
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| 73 | ATM
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| Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
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| Ambrose M, Goldstine JV, Gatti RA.
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| Hum Mol Genet 16(18):2154-64. Epub 2007 Jul 2. 2007
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| 74 | ATM, ATR, TERF2, POT1
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| Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
|
| Denchi EL, de Lange T.
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| Nature 448(7157):1068-71. Epub 2007 Aug 8. 2007
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| 75 | ATMIN, NBS1, ATM
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| ATMIN defines an NBS1-independent pathway of ATM signalling.
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| Kanu N, Behrens A.
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| EMBO J 26(12):2933-41. Epub 2007 May 24. 2007
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| 76 | ATM
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| Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
|
| Jiang Y, Liang ZD, Wu TT, Cao L, Zhang H, Xu XC.
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| Int J Cancer 120(1):91-5.
2007
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| 77 | ATM
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| Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.
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| Zhou T, Chou J, Zhou Y, Simpson DA, Cao F, Bushel PR, Paules RS, Kaufmann WK.
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| Mol Cancer Res 5(8):813-22.
2007
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| 78 | ATM
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| Tel1p preferentially associates with short telomeres to stimulate their elongation.
|
| Hector RE, Shtofman RL, Ray A, Chen BR, Nyun T, Berkner KL, Runge KW.
|
| Mol Cell 27(5):851-8.PMID: 17803948 2007
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| 79 | ATM, TOP1
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| ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
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| Gorodetsky E, Calkins S, Ahn J, Brooks PJ.
|
| DNA Repair (Amst) 6(11):1698-707. Epub 2007 Aug 13.PMID: 17706468 2007
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| 80 | ATM, TP53, MYC
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| ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
|
| Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG.
|
| Proc Natl Acad Sci U S A 103(5):1446-51. Epub 2006 Jan 23. 2006
|
| 81 | ATM, TP53, MTCL
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| Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma.
|
| Greiner TC, Dasgupta C, Ho VV, Weisenburger DD, Smith LM, Lynch JC, Vose JM, Fu K, Armitage JO, Braziel RM, Campo E, Delabie J, Gascoyne RD, Jaffe ES, Muller-Hermelink HK, Ott G, Rosenwald A, Staudt LM, Im MY, Karaman MW, Pike BL, Chan WC, Hacia JG.
|
| Proc Natl Acad Sci U S A 103(7):2352-7. Epub 2006 Feb 3. 2006
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| 82 | ATM
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| Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
|
| Kim JH, Kim H, Lee KY, Choe KH, Ryu JS, Yoon HI, Sung SW, Yoo KY, Hong YC.
|
| Hum Mol Genet 15(7):1181-6. Epub 2006 Feb 23. 2006
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| 83 | ATM
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| ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.
|
| Bredemeyer AL, Sharma GG, Huang CY, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH, Sleckman BP.
|
| Nature 442(7101):466-70. Epub 2006 Jun 14. 2006
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| 84 | ATM
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| ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.
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| Renwick A, Thompson D, Seal S, Kelly P, Chagtai T, Ahmed M, North B, Jayatilake H, Barfoot R, Spanova K, McGuffog L, Evans DG, Eccles D; Breast Cancer Susceptibility Collaboration (UK); Easton DF, Stratton MR, Rahman N.
|
| Nat Genet 38(8):873-5. Epub 2006 Jul 9. 2006
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| 85 | ATM
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| ATM promoter analysis in childhood lymphoid malignancies: a brief communication.
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| Gumy-Pause F, Wacker P, Maillet P, Betts DR, Sappino AP.
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| Leuk Res 30(3):335-7. Epub 2005 Aug 25. 2006
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| 86 | ATM, RAD50, NBN
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| Active role for nibrin in the kinetics of atm activation.
|
| Cerosaletti K, Wright J, Concannon P.
|
| Mol Cell Biol 26(5):1691-9. 2006
|
| 87 | RAD54L, ATM
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| Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
|
| Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL.
|
| J Clin Oncol 24(11):1720-8. Epub 2006 Mar 6. 2006
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| 88 | MRE11A, ATLD, ATM
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| Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
|
| Fernet M, Gribaa M, Salih MA, Seidahmed MZ, Hall J, Koenig M.
|
| Hum Mol Genet 14(2):307-18. Epub 2004 Dec 01. 2005
|
| 89 | KLRK1, ATR, ATM, CHEK1
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| The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
|
| Gasser S, Orsulic S, Brown EJ, Raulet DH.
|
| Nature 436(7054):1186-90. Epub 2005 Jul 3. 2005
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| 90 | ATM, COQ7, GZMB, GZMH
|
| Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
|
| Winrow CJ, Pankratz DG, Vibat CR, Bowen TJ, Callahan MA, Warren AJ, Hilbush BS, Wynshaw-Boris A, Hasel KW, Weaver Z, Lockhart DJ, Barlow C.
|
| Hum Mol Genet 14(18):2671-84. Epub 2005 Aug 8. 2005
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| 91 | ATM, ATR
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| Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
|
| Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.
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| J Biol Chem 280(2):1186-92. Epub 2004 Nov 8. 2005
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| 92 | ATM
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| Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
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| Lai CH, Chun HH, Nahas SA, Mitui M, Gamo KM, Du L, Gatti RA.
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| Proc Natl Acad Sci U S A 101(44):15676-81. Epub 2004 Oct 21. 2004
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| 93 | ATM
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| Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
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| Goodarzi AA, Lees-Miller SP.
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| DNA Repair (Amst) 3(7):753-67. 2004
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| 94 | ATM, ATR, DCLRE1C
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| Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
|
| Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ.
|
| Mol Cell Biol 24(20):9207-20. 2004
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| 95 | PAXIP1, TP53, ATM
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| Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.
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| Jowsey PA, Doherty AJ, Rouse J.
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| J Biol Chem 279(53):55562-9. Epub 2004 Sep 27. 2004
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| 96 | ATM, MTCL
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| ATM gene and lymphoid malignancies.
|
| Gumy-Pause F, Wacker P, Sappino AP.
|
| Leukemia 18(2):238-42. Review. 2004
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| 97 | ATM
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| Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia
|
| Tchirkov A, Lansdorp PM.
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| Hum Mol Genet 12(3):227-32. 2003
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| 98 | ATM
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| ATM missense mutations are frequent in patients with breast cancer.
|
| Sommer SS, Jiang Z, Feng J, Buzin CH, Zheng J, Longmate J, Jung M, Moulds J, Dritschilo A.
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| Cancer Genet Cytogenet 145(2):115-20. 2003
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| 99 | ATM, CHEK2, TP53
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| Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
|
| Keramaris E, Hirao A, Slack RS, Mak TW, Park DS.
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| J Biol Chem 278(39):37782-9. Epub 2003 Jul 11. 2003
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| 100 | ATM
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| A new type of mutation causes a splicing defect in ATM.
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| Pagani F, Buratti E, Stuani C, Bendix R, Dork T, Baralle FE.
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| Nat Genet 30(4):426-9. 2002
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| 101 | ATM, FANCD2
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| Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
|
| Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D'Andrea AD.
|
| Cell 109(4):459-72. 2002
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| 102 | ATM
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| Late appearance of the 11q22.3-23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significance.
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| Cuneo A, Bigoni R, Rigolin GM, Roberti MG, Bardi A, Cavazzini F, Milani R, Minotto C, Tieghi A, Della Porta M, Agostini P, Tammiso E, Negrini M, Castoldi G.
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| Haematologica 87(1):44-51. 2002
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| 103 | ATM, CDC25A, CHEK2
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| The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
|
| Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J.
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| Nature 410(6830):842-7. 2001
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| 104 | ATM, ATR, TREX1, WRN
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| ATR and ATRIP: partners in checkpoint signaling.
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| Cortez D, Guntuku S, Qin J, Elledge SJ.
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| Science 294(5547):1713-6. 2001
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| 105 | ATM, TRIM10, TRIM11, TRIM14, TRIM15, TRIM16, TRIM17, TRIM2, TRIM22, TRIM26, TRIM28, TRIM29, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM4, TRIM42, TRIM5, TRIM6, TRIM7, TRIM8, TRIM9, TRIMP1
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| The tripartite motif family identifies cell compartments.
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| Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A.
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| EMBO J 20(9):2140-51. 2001
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| 106 | ATM
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| The controlling role of ATM in homologous recombinational repair of DNA damage.
|
| Morrison C, Sonoda E, Takao N, Shinohara A, Yamamoto Ki, Takeda S.
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| EMBO J 19(3):463-471 2000
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| 107 | ATM, MTCL
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| Mantle cell lymphoma is characterized by inactivation of the ATM gene.
|
| Schaffner C, Idler I, Stilgenbauer S, Dohner H, Lichter P.
|
| Proc Natl Acad Sci U S A 97(6):2773-8. 2000
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| 108 | ATM
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| ATM-heterozygous germline mutations contribute to breast cancer-susceptibility.
|
| Broeks A, Urbanus JH, Floore AN, Dahler EC, Klijn JG, Rutgers EJ, Devilee P, Russell NS, van Leeuwen FE, van't Veer LJ.
|
| Am J Hum Genet 66(2):494-500. 2000
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| 109 | ATM
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| Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients.
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| Li A, Swift M.
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| Am J Med Genet 92(3):170-7. 2000
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| 110 | ATM, BRCA1
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| Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.
|
| Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH.
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| Nature 406(6792):210-5. 2000
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| 111 | ATM
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| ATM gene deletion in patients with adult acute lymphoblastic leukemia.
|
| Haidar MA, Kantarjian H, Manshouri T, Chang CY, O'Brien S, Freireich E, Keating M, Albitar M.
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| Cancer 88(5):1057-62. 2000
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| 112 | ATM
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| Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity.
|
| Becker-Catania SG, Chen G, Hwang MJ, Wang Z, Sun X, Sanal O, Bernatowska-Matuszkiewicz E, Chessa L, Lee EY, Gatti RA.
|
| Mol Genet Metab 70(2):122-33. 2000
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| 113 | ATM, BAX
|
| Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
|
| Chong MJ, Murray MR, Gosink EC, Russell HR, Srinivasan A, Kapsetaki M, Korsmeyer SJ, McKinnon PJ.
|
| Proc Natl Acad Sci U S A 97(2):889-94. 2000
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| 114 | ATM
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| Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases.
|
| Hotti A, Jarvinen K, Siivola P, Holtta E.
|
| Oncogene 19(19):2354-62. 2000
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| 115 | ATM
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| Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium.
|
| Bonnen PE, Story MD, Ashorn CL, Buchholz TA, Weil MM, Nelson DL.
|
| Am J Hum Genet 67(6):1437-51. 2000
|
| 116 | ATM
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| A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer.
|
| Maillet P, Chappuis PO, Vaudan G, Dobbie Z, Muller H, Hutter P, Sappino AP.
|
| Int J Cancer 88(6):928-31. 2000
|
| 117 | ATM
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| Characterization of ATM gene mutations in 66 ataxia telangiectasia families.
|
| Sandoval N, Platzer M, Rosenthal A, Dork T, Bendix R, Skawran B, Stuhrmann M, Wegner RD, Sperling K, Banin S, Shiloh Y, Baumer A, Bernthaler U, Sennefelder H, Brohm M, Weber BH, Schindler D.
|
| Hum Mol Genet 8 : 69-79. 1999
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| 118 | ATM
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| Multiple ATM-dependent pathways : an explanation for pleiotropy.
|
| Brown DK, et al.
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| Am J Hum Genet 64 : 46-50. 1999
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| 119 | ATM
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| Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences.
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| Teraoka SN, et al.
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| Am J Hum Genet 64(6):1617-31. 1999
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| 120 | ATM
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| New mutations, polymorphisms, and rare variants in the ATM gene detected by a novel SSCP strategy.
|
| Castellvi-Bel S, et al.
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| Hum Mutat 14(2):156-62. 1999
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| 121 | ATM
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| Breast cancer risk in ataxia telangiectasia (AT) heterozygotes: haplotype study in French AT families.
|
| Janin N, et al.
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| Br J Cancer 80(7):1042-5. 1999
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| 122 | ATM, ATM
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| Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
|
| Barlow C, et al.
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| Proc Natl Acad Sci U S A 96(17):9915-9 1999
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| 123 | ATM
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| Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.
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| Schaffner C, et al.
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| Blood 94(2):748-53 1999
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| 124 | ATM
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| Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.
|
| Smith GC, Cary RB, Lakin ND, Hann BC, Teo SH, Chen DJ, Jackson SP.
|
| Proc Natl Acad Sci U S A 96(20):11134-9 1999
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| 125 | ATM, BRCA1
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| Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
|
| Cortez D, Wang Y, Qin J, Elledge SJ.
|
| Science 286(5442):1162-6 1999
|
| 126 | ATM, ST3
|
| Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma.
|
| Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Moller P, Muller-Hermelink HK, James MR, Lichter P, Dohner H.
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| Blood 94(9):3262-4 1999
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| 127 | ATM
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| Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations.
|
| Gatti RA, Tward A, Concannon P.
|
| Mol Genet Metab 68(4):419-23. Review. 1999
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| 128 | ATM, ATM
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| Ataxia-telangiectasia without immunodeficiency : novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain.
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| Toyoshima M, Hara T, Zhang H, Yamamoto T, Akaboshi S, Nanba E, Ohno K, Hori N, Sato K, Takeshita K.
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| Am J Med Genet 75(2):141-4. 1998
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| 129 | ATM
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| Ataxia-telangiectasia : identification and detection of founder-effect mutations in the ATM gene in ethnic populations.
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| Telatar M, Teraoka S, Wang Z, Chun HH, Liang T, Castellvi-Bel S, Udar N, Borresen-Dale AL, Chessa L, Bernatowska-Matuszkiewicz E, Porras O, Watanabe M, Junker A, Concannon P, Gatti RA.
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| Am J Hum Genet 62(1):86-97. 1998
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| 130 | ATM
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| ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles : expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer.
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| Stankovic T, Kidd AM, Sutcliffe A, McGuire GM, Robinson P, Weber P, Bedenham T, Bradwell AR, Easton DF, Lennox GG, Haites N, Byrd PJ, Taylor AM.
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| Am J Hum Genet 62(2):334-45. 1998
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| 131 | ATM, ATM
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| Genotype-Phenotype relationships in ataxia-telangiectasia and variants.
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| Gilad S, et al.
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| Am J Hum Genet 62 : 551-561. 1998
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| 132 | ATM, ATM
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| Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients : possible preponderance of the two founder mutations 4612del165 and 7883del5.
|
| Ejima Y, et al.
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| Hum Genet 102 : 403-408. 1998
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| 133 | ATM, TP53
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| ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.
|
| Waterman MJF, et al.
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| Nat Genet 19 : 175-178. 1998
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| 134 | ATM, ATM
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| ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy.
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| Sasaki T, et al.
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| Hum Mutat 12 : 186-195. 1998
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| 135 | ATM
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| ATM binds to beta-adaptin in cytoplasmic vesicles.
|
| Lim DS, et al.
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| Proc Natl Acad Sci U S A 95 : 10146-10151. 1998
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| 136 | ATM
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| The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia.
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| Takeuchi S, et al.
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| Br J Haematol 103 : 536-538. 1998
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| 137 | ATM
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| Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity.
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| Gately DP, et al.
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| Mol Biol Cell 9 : 2361-2374. 1998
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| 138 | ATM
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| ATM associates with and phosphorylates p53 : mapping the region of interaction.
|
| Khanna KK, et al.
|
| Nat Genet 20 : 398-400. 1998
|
| 139 | ATM, ST3
|
| Expression of the ATM gene is significantly reduced in sporadic breast carcinomas.
|
| Waha A, et al.
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| Int J Cancer 78 : 306-309. 1998
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| 140 | ATM
|
| Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia.
|
| Takagi M, et al.
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| Cancer Res 58 : 4923-4929. 1998
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| 141 | ATM, ATR, BLM, MLH1, RAD51, RPA1, RPA2, RPA3
|
| Changes in protein composition of meiotic nodules during mammalian meiosis.
|
| Plug AW, et al.
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| J Cell Sci 111 ( Pt 4):413-23. 1998
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| 142 | ATM, ST3
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| Heterozygous ATM mutations do not contribute to early onset of breast cancer.
|
| FitzGerald MG, et al.
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| Nat Genet 15 : 307-310. 1997
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| 143 | ATM, ATM, NPAT, HERVK10N, HERVL2, CUL5
|
| Construction of a transcription map around the gene for ataxia telangiectasia : identification of at least four novel genes.
|
| Stankovic T, et al.
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| Genomics 40 : 267-276. 1997
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| 144 | ATM
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| The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.
|
| Brown KD, et al.
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| Proc Natl Acad Sci U S A 94 : 1840-1845. 1997
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| 145 | ATM, NPAT
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| CAND3 : a ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 11q23.1.
|
| Chen X, et al.
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| Mamm Genome 8 : 129-133. 1997
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| 146 | ATM
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| Ataxia-telangiectasia : structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.
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| Savitsky K, et al.
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| Nucleic Acids Res 25 : 1678-1684. 1997
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| 147 | ATM
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| Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.
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| Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, Gilad S, Shiloh Y, Rosenthal A.
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| Genome Res 7(6):592-605. 1997
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| 148 | ATM
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| Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
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| Zhang N, Chen P, Khanna KK, Scott S, Gatei M, Kozlov S, Watters D, Spring K, Yen T, Lavin MF.
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| Proc Natl Acad Sci U S A 94(15):8021-6. 1997
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| 149 | ATM
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| Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia.
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| Concannon P, Gatti RA.
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| Hum Mutat 10(2):100-7. Review. 1997
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| 150 | ATM
|
| Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.
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| Vorechovsky I, Luo L, Dyer MJ, Catovsky D, Amlot PL, Yaxley JC, Foroni L, Hammarstrom L, Webster AD, Yuille MA.
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| Nat Genet 17(1):96-9. 1997
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| 151 | ATM, ST3
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| Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.
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| Stilgenbauer S, Schaffner C, Litterst A, Liebisch P, Gilad S, Bar-Shira A, James MR, Lichter P, Dohner H.
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| Nat Med 3(10):1155-9. 1997
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| 152 | ATM
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| ATM and RPA in meiotic chromosome synapsis and recombination.
|
| Plug AW, Peters AH, Xu Y, Keegan KS, Hoekstra MF, Baltimore D, de Boer P, Ashley T.
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| Nat Genet 17(4):457-61. 1997
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| 153 | ATM
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| Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.
|
| Barlow C, Brown KD, Deng CX, Tagle DA, Wynshaw-Boris A.
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| Nat Genet 17(4):453-6. Erratum in: Nat Genet 1998 Mar;18(3):298. 1997
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| 154 | ATM
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| Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.
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| Byrd P, et al.
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| Hum Mol Genet 5 : 145-149. 1996
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| 155 | ATM
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| Predominance of null mutations in ataxia-telangiectasia.
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| Gilad S, et al.
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| Hum Mol Genet 5 : 433-439. 1996
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| 156 | ATM
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| Genomic organization of the ATM gene.
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| Uziel T, et al.
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| Genomics 33 : 317-320. 1996
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| 157 | ATM
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| Ataxia-telangiectasia : mutations in ATM cDNA detected by protein-truncation screening.
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| Telatar M, et al.
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| Am J Hum Genet 59 : 40-44. 1996
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| 158 | ATM
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| New mutations in the ataxia telangiectasia gene.
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| Baumer A, et al.
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| Hum Genet 98 : 246-249. 1996
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| 159 | ATM
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| Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
|
| Pecker I, et al.
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| Genomics 35 : 39-45. 1996
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| 160 | ATM, NPAT
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| Identification and characterization of a new gene physically linked to the ATM gene.
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| Genome Res 6 : 439-447. 1996
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| 161 | ATM
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| Atm-deficient mice : a paradigm of ataxia telangiectasia.
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| Cell 86 : 159-171. 1996
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| 162 | ATM
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| Mutations associated with variant phenotypes in ataxia-telangiectasia.
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| 163 | ATM
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| A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.
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| 164 | ATM, NPAT
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| Physical map and two new transcripts surrounding the ataxia-telangiectasia gene at chromosome 11q23. (abstr)
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| Am J Hum Genet 59 : A407. 1996
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| 165 | ATM, ST3
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| ATM mutations in cancer families.
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| Cancer Res 56 : 4130-4133. 1996
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| 166 | ATM, FHIT, DLEC1, ST3
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| High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and grade I tubular invasive breast cancers.
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| Man S, et al.
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| Cancer Res 56 : 5484-5489. 1996
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| 167 | ATM
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| Exon-scanning mutation analysis of the ATM gene in patients with ataxia-telangiectasia.
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| Eur J Hum Genet 4 : 352-355. 1996
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| 168 | ATM
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| The product of the ATM gene is a 370-kDa nuclear phosphoprotein.
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| Chen G, et al.
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| J Biol Chem 271 : 33693-33697. 1996
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| 169 | ACAT1, ATM, CRYAB, FDX1, FGF3, GRIA4, NCAM1, D11S1818, D11S1897, D11S1960, D11S2
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| Generation of a panel of radiation-reduced hybrids containing human 11q22-23 fragments bearing a HPRT selective marker : identification of hybrids carrying various subregions around the ataxia-telangiectasia locus.
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| Ejima Y, et al.
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| Somat Cell Mol Genet 22 : 499-509. 1996
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| 170 | ATM
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| Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
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| Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P.
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| Proc Natl Acad Sci U S A 93(23):13084-9. 1996
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| 171 | ATM
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| Dual roles of ATM in the cellular response to radiation and in cell growth control.
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| Xu Y, Baltimore D.
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| Genes Dev 10(19):2401-10. 1996
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| 172 | ATM
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| Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders.
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| Stilgenbauer S, Liebisch P, James MR, Schroder M, Schlegelberger B, Fischer K, Bentz M, Lichter P, Dohner H.
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| Proc Natl Acad Sci U S A 93(21):11837-41. Erratum in: Proc Natl Acad Sci U S A 1996 Dec 10;93(25):14992. 1996
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| 173 | ATM, XRCC6, XRCC5, PRKDC
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| DNA-dependent protein kinase catalytic subunit : a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
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| Hartley KO, et al.
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| Cell 82 : 849-856. 1995
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| 174 | ATM
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| ATM-related genes : what do they tell us about functions of the human gene ?
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| Zakian VA.
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| Cell 82 : 685-687. 1995
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| 175 | ATM
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| The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.
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| Savitsky K, et al.
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| Hum Mol Genet 11 : 2025-2032. 1995
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| 176 | ATM
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| TEL1 an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.
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| Morrow DM, et al.
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| Cell 82 : 831-840. 1995
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| 177 | ATM
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| TEL1, a gene involved in controlling telomere length is S. cerevisae, is homologous to the human ataxia telangiectasia gene.
|
| Greenwell PW, et al.
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| Cell 82 : 823-829. 1995
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| 178 | ATM
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| The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene.
|
| Hari KL, et al.
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| Cell 82 : 815-821. 1995
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| 179 | ATM
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| Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells.
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| Ziv Y, et al.
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| Somat Cell Mol Genet 21 : 99-111. 1995
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| 180 | ATM, ST3
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| Genomic organization of the ATM locus involved in ataxia-telangiectasia.
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| Rasio D, et al.
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| Cancer Res 55 : 6053-6057. 1995
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| 181 | ATM
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| A high-density microsatellite map of the ataxia-telangiectasia locus.
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| Vanagaite L, et al.
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| Hum Genet 95 : 451-454. 1995
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| 182 | ATM
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| A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
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| Savitsky K, et al.
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| Science 268 : 1749-1753. 1995
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| 183 | ATM, D11S384
|
| Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families.
|
| Uhrhammer N, et al.
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| Am J Hum Genet 57 : 103-111. 1995
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| 184 | ATM
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| Localization of an ataxia-telangiectasia gene to an ~500-kb interval on chromosome 11q23.1 : linkage analysis of 176 families by an international consortium.
|
| Lange E, et al.
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| Am J Hum Genet 57 : 112-119. 1995
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| 185 | ATM, HINT1, TRIM29
|
| The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
|
| Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF.
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| Proc Natl Acad Sci U S A 92(17):7824-8. 1995
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| 186 | ATM
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| Ordering markers in the region of the ataxia-telangiectasia gene (11q22-q23) by fluorescence in situ hybridization (FISH) to interphase nuclei.
|
| Cherif D, et al.
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| Hum Genet 93 : 1-6. 1994
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| 187 | ATM
|
| Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC).
|
| Leonhardt EA, et al.
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| Genomics 19 : 130-136. 1994
|
| 188 | ATM
|
| A pulsed-field gel electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3.
|
| Uhrhammer N, et al.
|
| Genomics 20 : 278-280. 1994
|
| 189 | ATM
|
| A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia.
|
| Ambrose HJ, et al.
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| Genomics 21 : 612-619. 1994
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| 190 | ATM
|
| Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23.
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| Vanagaite L, et al.
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| Genomics 22 : 231-233. 1994
|
| 191 | ATM, D11S1817, D11S1818, D11S1819
|
| Three dinucleotide repeat polymorphisms at the ataxia-telangiectasia locus.
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| Rotman G, et al.
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| Hum Mol Genet 3 : 2079. 1994
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| 192 | ATM
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| A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23.
|
| Rotman G, et al.
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| Genomics 24 : 234-242. 1994
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| 193 | ATM
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| Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.
|
| Meyn MS, et al.
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| Am J Hum Genet 53 : 1206-1216. 1993
|
| 194 | ATM
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| Prenatal genotyping of ataxia-telanglectasia.
|
| Gatti RA, et al.
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| Lancet 342 : 376. 1993
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| 195 | ATM, D11S535, D11S611
|
| Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23.
|
| McConville CM, et al.
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| Hum Mol Genet 2 : 969-974. 1993
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| 196 | ATM, TRIM29
|
| A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus.
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| Richard CW 3rd, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR.
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| Genomics 17(1):1-5. 1993
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| 197 | ATM
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| Ataxia-telangiectasia : linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome.
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| Ziv Y, et al.
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| Hum Genet 88 : 619-626. 1992
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| 198 | ATM
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| Ataxia-telangiectasia : linkage evidence for genetic heterogeneity.
|
| Sobel E, et al.
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| Am J Hum Genet 50 : 1343-1348. 1992
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| 199 | ATM
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| Cloning of a candidate gene for ataxia-telangiectasia group D.
|
| Kapp LN, et al.
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| Am J Hum Genet 51 : 45-54. 1992
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| 200 | ATM
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| Ataxia-telangiectasia : linkage analysis of chromosome 11q22-23 markers in Turkish families.
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| Sanal O, et al.
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| FASEB J 6 : 2848-2852. 1992
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| 201 | ATM
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| Ataxia telangiectasia : isolation of candidate cDNAs from an EBV-based human cDNA library by phenotypic complementation and plasmid rescue.
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| Meyn MS, et al.
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| Am J Hum Genet 51 : A22. 1992
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| 202 | ATM
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| Genetic and physical mapping of an ataxia-telangiectasia locus on chromosome 11q22-23.
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| Heim RA, et al.
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| Am J Hum Genet 51 : A190. 1992
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| 203 | ATM
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| Functional complementation of ataxia-telangiectasia group D (AT-D) cells by microcell-mediated chromosome transfer and mapping of the AT-D locus to the region 11q22-23.
|
| Lambert C, et al.
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| Proc Natl Acad Sci U S A 88 : 5907-5911. 1991
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| 204 | ATM
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| Linkage analyses with 11q23 markers in Norwegian AT families.
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| Bšrresen AL, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1955. 1991
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| 205 | ATM
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| Failure to map the AT gene to 11q22.23 in a large inbred family.
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| Hernandez D, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1962-1963. 1991
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| 206 | D11S535, ATM
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| J12.8 (D11S535), a new DNA marker which flanks the ataxia telangiectasia locus on chromosome 11q22-q23.
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| McConville CM, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1967. 1991
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| 207 | ATM
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| Genetic and physical mapping of chromosome 11q markers near the ataxia-telangiectasia locus.
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| Lench N, et al.
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| Am J Hum Genet 49S : 348. 1991
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| 208 | ATM
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| The gene for ataxia telangiectasia is flanked by the markers D11S424 and D11S385/STMY/D11S35 on chromosome 11q22-23 in 45 British families.
|
| McConville CM, et al.
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| Am J Hum Genet 49S : 350. 1991
|
| 209 | ATM
|
| Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23 : linkage analysis of 111 families by an international consortium.
|
| Foroud T, et al.
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| Am J Hum Genet 49 : 1263-1279. 1991
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| 210 | ATM
|
| The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
|
| Ziv Y, et al.
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| Genomics 9 : 373-375. 1991
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| 211 | ATM
|
| The ataxia-telangiectasia gene (ATA) on chromosome 11 is distinct from the ETS-1 gene.
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| Concannon P, et al.
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| Am J Hum Genet 46 : 789-794. 1990
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| 212 | ATM
|
| Analysis of 7 polymorphic markers at chromosome 11q22-23 in 35 ataxia telangiectasia families; further evidence of linkage.
|
| McConville CM, et al.
|
| Hum Genet 85 : 215-220. 1990
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| 213 | ATM, CBL
|
| Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus.
|
| Wei S, et al.
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| Cancer Genet Cytogenet 46 : 1-8. 1990
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| 214 | ATM
|
| Chromosome 11 contains genes for the three most common complementation groups of ataxia-telangiectasia: a consortium report.
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| Gatti RA, et al.
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| Am J Hum Genet 47 : A179. 1990
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| 215 | ATM
|
| Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
|
| Sanal O, et al.
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| Am J Hum Genet 47 : 860-866. 1990
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| 216 | ATM
|
| Abnormality in DNA-protein binding in ataxia telangiectasia nuclear extracts.
|
| Mohamed R, et al.
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| Biochem Biophys Res Commun 158 : 749-754. 1989
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| 217 | ATM
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| The ataxia-telangiectasia (A-T) locus in jewish and arab patients localizes to 11q22-23.
|
| Shiloh Y, et al.
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| Am J Hum Genet 45 : A161. 1989
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| 218 | ATM
|
| Localization of an ataxia-telangiectasia gene to chromosome 11q22-23.
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| Gatti RA, Berkel I, Boder E, Braedt G, Charmley P, Concannon P, Ersoy F, Foroud T, Jaspers NG, Lange K, et al.
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| Nature 336 : 577-580. 1988
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| 219 | ATM
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| Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome : a survey of 50 patients.
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| Jaspers NGJ, et al.
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| Cytogenet Cell Genet 49 : 259-263. 1988
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| 220 | ATM
|
| Molecular characterization of the breakpoints in ataxia telangiectasia T cell proliferations.
|
| Stern MH, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 699. 1987
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