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FLASH GENE
Symbol GOT1 contributors: mct/npt - updated : 26-05-2010
HGNC name glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
HGNC id 4432
Location 10q24.2      Physical location : 101.156.627 - 101.190.530
Synonym name
  • aspartate aminotransferase 1
  • growth-inhibiting protein 18
  • transaminase A
  • Synonym symbol(s) AATC, GIG18
    EC.number 2.6.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 33.90 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see WNT8B
    Physical map
    C10orf28 10q24.2 chromosome 10 open reading frame 28 LOXL4 10q24 lysyl oxidase-like 4 C10orf33 10q24.2 chromosome 10 open reading frame 33 HPS1 10q23.1-q23.3 Hermansky-Pudlak syndrome 1 HPSE2 10q23-q24 heparanase 2 CNNM1 10q24.33 cyclin M1 GOT1 10q24 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) NKX2-3 10q24.33 NK2 transcription factor related, locus 3 (Drosophila) SLC25A28 10q24 solute carrier family 25, member 28 LALP1 10q23-q24 solute carrier family 25, member 28 COX15 10q24 COX15 homolog, cytochrome c oxidase assembly protein (yeast) CGI-32 10q24.31 CGI-32 protein ABCC2 10q24 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 KIAA1010 10q25.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 CPN1 10q24.31 carboxypeptidase N, polypeptide 1, 50kD KEO4 CHUK 10q24-q25 conserved helix-loop-helix ubiquitous kinase FLJ10998 10q24.31 hypothetical protein FLJ10998 MGC10120 10q24.31 hypothetical protein MGC10120 PKD2L1 10q24-q25 polycystic kidney disease 2-like 1 SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2140 - 413 - Panteghini (1990)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinethyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    text efficiently packaged into COPII vesicles and cycled rapidly between the ER and Golgi compartments (Lorente-Rodríguez 2009)
    basic FUNCTION
  • playing a role in amino acid metabolism and the urea and tricarboxylic acid cycles
  • may have an unexpected role in vesicle formation from the ER by influencing membrane properties (Lorente-Rodríguez 2009)
  • is essential for redox balance and growth in pancreatic ductal adenocarcinoma
  • GOT1 may play a role in the maintenance of cellular redox homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal-phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome (Struski 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    therapy target in pancreatic ductal adenocarcinoma (PDAC)
    ANIMAL & CELL MODELS