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FLASH GENE

Symbol

WFDC1

contributors: mct/npt - updated : 16-10-2009

HGNC name	WAP four-disulfide core domain 1
HGNC id	15466

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in senescent fibroblasts (Madar 2009) constitutional     --low   but not frequently mutated in prostate cancer (Watson 2004) tumoral   LOH     in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene	downregulation of WFDC1 might serve as a biomarker for cellular transformation (Madar 2009)
Marker
Therapy target

ANIMAL & CELL MODELS