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FLASH GENE
Symbol WFDC1 contributors: mct/npt - updated : 16-10-2009
HGNC name WAP four-disulfide core domain 1
HGNC id 15466
DNA
TYPE functioning gene
STRUCTURE 35.05 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1396 - 220 - Larsen (2000)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text mesenchymal urogenital sinus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a whey acidic protein-type (Wap) four-disulfide core domain, characterized by serine protease inhibition activity in a number of whey acidic protein domain-containing proteins (McAlhany 2003)
  • eight cysteines forming four disulfide bonds at the core of protein
  • HOMOLOGY
    interspecies homolog to rattus Ps20
    homolog to C.elegans Moc1
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes endothelial cell motility but has no effect on endothelial cell proliferation (McAlhany 2003)
  • may be a TGF-beta1-induced regulator of angiogenesis that functions by either promoting endothelial cell migration or by contributing to pericyte stabilization of newly formed vascular structures (McAlhany 2003)
  • not classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate (Watson 2004)
  • playing an essential role in mammalian eye development (Abbasi 2009)
  • playing an important role in inhibiting proliferation of both tumors and senescent cells (Madar 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in senescent fibroblasts (Madar 2009)
    constitutional     --low  
    but not frequently mutated in prostate cancer (Watson 2004)
    tumoral   LOH    
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene downregulation of WFDC1 might serve as a biomarker for cellular transformation (Madar 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS