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FLASH GENE
Symbol WFDC1 contributors: mct/npt - updated : 16-10-2009
HGNC name WAP four-disulfide core domain 1
HGNC id 15466
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a whey acidic protein-type (Wap) four-disulfide core domain, characterized by serine protease inhibition activity in a number of whey acidic protein domain-containing proteins (McAlhany 2003)
  • eight cysteines forming four disulfide bonds at the core of protein
    • HOMOLOGY
    interspecies homolog to rattus Ps20
    homolog to C.elegans Moc1
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes endothelial cell motility but has no effect on endothelial cell proliferation (McAlhany 2003)
  • may be a TGF-beta1-induced regulator of angiogenesis that functions by either promoting endothelial cell migration or by contributing to pericyte stabilization of newly formed vascular structures (McAlhany 2003)
  • not classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate (Watson 2004)
  • playing an essential role in mammalian eye development (Abbasi 2009)
  • playing an important role in inhibiting proliferation of both tumors and senescent cells (Madar 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in senescent fibroblasts (Madar 2009)
    constitutional     --low  
    but not frequently mutated in prostate cancer (Watson 2004)
    tumoral   LOH    
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene downregulation of WFDC1 might serve as a biomarker for cellular transformation (Madar 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS