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FLASH GENE
Symbol WFDC1 contributors: mct/npt - updated : 16-10-2009
HGNC name WAP four-disulfide core domain 1
HGNC id 15466
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text mesenchymal urogenital sinus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a whey acidic protein-type (Wap) four-disulfide core domain, characterized by serine protease inhibition activity in a number of whey acidic protein domain-containing proteins (McAlhany 2003)
  • eight cysteines forming four disulfide bonds at the core of protein
    • HOMOLOGY
    interspecies homolog to rattus Ps20
    homolog to C.elegans Moc1
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes endothelial cell motility but has no effect on endothelial cell proliferation (McAlhany 2003)
  • may be a TGF-beta1-induced regulator of angiogenesis that functions by either promoting endothelial cell migration or by contributing to pericyte stabilization of newly formed vascular structures (McAlhany 2003)
  • not classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate (Watson 2004)
  • playing an essential role in mammalian eye development (Abbasi 2009)
  • playing an important role in inhibiting proliferation of both tumors and senescent cells (Madar 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in senescent fibroblasts (Madar 2009)
    constitutional     --low  
    but not frequently mutated in prostate cancer (Watson 2004)
    tumoral   LOH    
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene downregulation of WFDC1 might serve as a biomarker for cellular transformation (Madar 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS