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FLASH GENE

Symbol

FUT2

contributors: mct - updated : 09-03-2016

HGNC name	fucosyltransferase 2 (secretor status included)
HGNC id	4013

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

H

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   altered expression of fucosylation pathway gene(FUT2), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)

Susceptibility

to variation of plasma vitamin B12 levels to variation in progression of HIV-1 infection to Crohn disease (CD) to Norovirus Infections to variation of human intestinal microbiota to type 1 diabetes to familial otitis media to intestinal-type gastric cancer

Variant & Polymorphism SNP	association of four SNPs and CD
	common variants of FUT2 are associated with plasma vitamin B12 levels
	nonsense mutation 428G-->A in the FUT2 gene associated with a slow disease progression of HIV-1 infection
	nonsecretor A/A genotype of rs601338A>G was found to confer susceptibility to type 1 diabetes
	secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota
	susceptibility to Norovirus infections influenced by FUT2 Genotype
	common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells
	variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer

Candidate gene
Marker	could be useful to predict breast cancer axillary lymph nodes metastasis )
Therapy target

ANIMAL & CELL MODELS