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FLASH GENE

Symbol

FUT2

contributors: mct - updated : 09-03-2016

HGNC name	fucosyltransferase 2 (secretor status included)
HGNC id	4013

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000511 2 - 3099 NP_000502 - 343 - 1995 7876234 NM_001097638 2 - 3089 NP_001091107 - 343 - 1995 7876234

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Lymphoid/Immune spleen       highly Reproductive male system testis     moderately Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular         Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Fut2
	ortholog to rattus Fut2

Homologene

FAMILY

glycosyltransferase 11 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein; membrane-bound form in trans cisternae of Golgi

basic FUNCTION	creating a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen
	synthesis pathway
	fucosyltransferase responsible for ABO biosynthesis in body fluids
	fucosyltransferase required for the biosynthesis of the terminal glycan motif
	novel role for FUT2 as a regulator of angiogenesis
	catalyzes fucose addition to form H-type antigens in exocrine secretions
	selection of mutualistic microorganisms of the intestinal microbiota is controlled by the FUT2 and FUT3 genes that encode fucosyltransferases, enzymes responsible for the synthesis of fucosylated glycan structures of mucins and milk oligosaccharides

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

glycosylation

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

macrophages regulate expression of FUT1, FUT2 genes in human endometrial epithelial cells

ASSOCIATED DISORDERS

corresponding disease(s)

H

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   altered expression of fucosylation pathway gene(FUT2), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)

Susceptibility

to variation of plasma vitamin B12 levels to variation in progression of HIV-1 infection to Crohn disease (CD) to Norovirus Infections to variation of human intestinal microbiota to type 1 diabetes to familial otitis media to intestinal-type gastric cancer

Variant & Polymorphism SNP	association of four SNPs and CD
	common variants of FUT2 are associated with plasma vitamin B12 levels
	nonsense mutation 428G-->A in the FUT2 gene associated with a slow disease progression of HIV-1 infection
	nonsecretor A/A genotype of rs601338A>G was found to confer susceptibility to type 1 diabetes
	secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota
	susceptibility to Norovirus infections influenced by FUT2 Genotype
	common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells
	variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer

Candidate gene
Marker	could be useful to predict breast cancer axillary lymph nodes metastasis )
Therapy target

ANIMAL & CELL MODELS