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FLASH GENE

Symbol

HDAC8

contributors: mct/npt - updated : 08-11-2015

HGNC name	histone deacetylase 8
HGNC id	13315

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CDLS5 , WTSL1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer tissues constitutional     --low   caused centrosome splitting, which could also be induced by depleting a centriole-linker protein, rootletin

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   HDAC8 inhibitors may have therapeutic potential for the treatment of myeloproliferative neoplasms (MPNs) cancer     HDAC8-targeting agents might be explored as an adjuvant for tumors carrying a mutant TP53

ANIMAL & CELL MODELS

deletion of Hdac8 in mice leads to perinatal lethality due to skull instability